Ceruloplasmin is a Better Predictor of the Long-Term Prognosis Compared with Fibrinogen, CRP, and IL-6 in Patients with Severe Unstable Angina
| Autor: | George D. Giannoglou, Antonios Ziakas, M. Arvanitidou Vayona, Christos Savopoulos, Sotirios Mochlas, Ifigenia Pidonia, George Parharidis, Efthimia Souliou, George Efthimiadis, Apostolos I. Hatzitolios, Ioannis Stiliadis, Stavros Gavrilidis, Haralambos Karvounis |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Fibrinogen Severity of Illness Index Gastroenterology Angina Troponin T Predictive Value of Tests Internal medicine Severity of illness medicine Humans Angina Unstable Interleukin 6 Aged Aged 80 and over biology Interleukin-6 business.industry Unstable angina C-reactive protein Ceruloplasmin Middle Aged Prognosis medicine.disease Up-Regulation Surgery Hospitalization C-Reactive Protein Cardiovascular Diseases Predictive value of tests biology.protein Female Cardiology and Cardiovascular Medicine business Biomarkers Follow-Up Studies medicine.drug |
| Zdroj: | Angiology. 60:50-59 |
| ISSN: | 1940-1574 0003-3197 |
| Popis: | Background. We investigated the time course and prognostic value of fibrinogen (Fib), C-reactive protein (CRP), interleukin-6 (IL-6), and ceruloplasmin (CP) in patients with severe unstable angina. Methods. All 4 substances were measured on admission and after 6, 12, 24, 48, and 72 hours, and after 7 days and 6 months in 40 patients with Braunwald's classification class IIIB unstable angina. Results. All recorded substances increased significantly; 15 patients had cardiovascular events during hospitalization and 11 patients during follow-up. The time course and the mean values of Fib, CRP, and IL-6 were similar in patients with and without complications both during hospitalization and follow-up. However, CP levels from 6 hours until 6 months were significantly higher in patients with complications during follow-up ( P < .05). Conclusions. Fib, CRP, IL-6, and CP levels alter in patients with severe unstable angina. However, only CP levels were related to 12-month follow-up prognosis. |
| Databáze: | OpenAIRE |
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