Protective Effects of Tanning on Cutaneous DNA Damage in situ

Autor:	Jan A. Marcusson, Vladimir J.N. Bykov, Kari Hemminki
Rok vydání:	2001
Předmět:	Adult Male In situ medicine.medical_specialty integumentary system Ultraviolet Rays DNA damage Sunburn Cancer Skin Pigmentation DNA Dermatology Biology medicine.disease Constitutive skin pigmentation medicine Humans Female Skin cancer DNA Damage Skin
Zdroj:	Karolinska Institutet
ISSN:	1421-9832 1018-8665
DOI:	10.1159/000051579
Popis:	Background: The incidence of skin cancer, the most common type of cancer in the Western world, has been shown to be associated with the degree of exposure to solar radiation. However, little is known on how human skin can be protected against UV-induced DNA damage by constitutive and induced pigmentation. Objective: To study the effect of skin pigmentation induced by a sunbed-type of treatment on the formation of UV-induced DNA damage in human skin in situ. Methods: A photoproduct assay was performed in untanned and tanned skin of healthy volunteers. Results: There is no significant difference in the induction of photoproducts between untanned and tanned skin. Conclusion: Our data demonstrate that constitutive skin pigmentation is more efficient than the induced one in protection against formation of photoproducts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553cb489b9b9b66c3ea27edb79e570e4 https://doi.org/10.1159/000051579 Zobrazit plný text záznamu