The emerging field of regulatory B cell immunometabolism
| Autor: | Claudia Mauri, Elizabeth C. Rosser |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Physiology Regulatory B cells medicine.medical_treatment B-Lymphocyte Subsets Biology 03 medical and health sciences 0302 clinical medicine Immune system Extracellular medicine Humans Molecular Biology B cell Inflammation Cell Biology Cell biology 030104 developmental biology medicine.anatomical_structure Cytokine biology.protein Cytokines Antibody 030217 neurology & neurosurgery Function (biology) Intracellular |
| Zdroj: | Cell Metabolism. 33:1088-1097 |
| ISSN: | 1550-4131 |
| Popis: | B cells are well known as critical mediators of humoral immune responses via the production of antibodies. However, numerous studies have also identified populations of B cells that are characterized by their anti-inflammatory properties. These "regulatory B cells" restrain excessive inflammatory responses in a wide range of health conditions. A significant knowledge gap remains concerning the nature of the signals that determine whether a B cell exerts a pro-inflammatory or anti-inflammatory function. In this perspective, we explore the concept that in addition to the cytokine microenvironment, intracellular and extracellular metabolic signals play a pivotal role in controlling the balance between regulatory and antibody-producing B cell subsets. Determining the metabolites and tissue-specific signals that influence B cell fate could establish novel therapeutic targets for the treatment of diseases where abnormal B cell responses contribute to pathogenesis. |
| Databáze: | OpenAIRE |
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