Thiamine Pyrophosphatase Activity in the Golgi Apparatus of Calcitonin-treated Osteoclasts
| Autor: | Takashi Tanaka, Yosuke Kuwahara, Yoshiki Nakamura, Koji Noda, Yasuo Wakimoto |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Calcitonin
musculoskeletal diseases medicine.medical_specialty Thiamine pyrophosphatase activity Golgi Apparatus Osteoclasts Bone resorption symbols.namesake Osteoclast Internal medicine medicine Thiamine pyrophosphatase Animals Secretion Instrumentation chemistry.chemical_classification Rats Inbred Strains Golgi apparatus Rats Endocrinology medicine.anatomical_structure Enzyme chemistry symbols sense organs Thiamine Pyrophosphatase |
| Zdroj: | Journal of Electron Microscopy. |
| ISSN: | 1477-9986 |
| DOI: | 10.1093/oxfordjournals.jmicro.a050915 |
| Popis: | The thiamine pyrophosphatase (TPPase) activity described by Novikoff and Goldfisher was examined in osteoclasts affected by calcitonin in order to elucidate whether the morphological and functional changes of the osteoclasts have an influence over the secretion function of their Golgi apparatus. The Golgi apparatus of osteoclasts of which the ruffled border had disappeared and bone resorption discontinued as the result of treatment with calcitonin showed a slight TPPase activity. The reaction products of the enzyme in these inactive osteoclasts were distinctly fewer than that of control osteoclasts, which were not affected by calcitonin. From these results, it is suggested that there may be a connection between the morphological and functional changes of osteoclasts and the secretion function of the Golgi apparatus. |
| Databáze: | OpenAIRE |
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