Bilateral injection-site granuloma by subcutaneous administration of luteinizing hormone-releasing hormone analogue: a case report
| Autor: | Toshiharu Hidaka, Shinichi Morishita, Riko Kitazawa, Fukashi Yamamichi, Kiyoshi Mori, Sohei Kitazawa, Takeshi Kondo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Medicine(all)
Pathology medicine.medical_specialty medicine.diagnostic_test business.industry General Medicine medicine.disease Abdominal wall medicine.anatomical_structure Leuprorelin Granuloma Biopsy Case report Medicine business Luteinizing hormone Infiltration (medical) Histiocyte Hormone medicine.drug |
| Zdroj: | Cases Journal |
| ISSN: | 1757-1626 |
| Popis: | We report a typical case of injection-site granuloma attributed to subcutaneous administration of leuprorelin acetate, an LHRH agonist. A 70-year-old man who had undergone total prostatectomy and was subsequently given leuprorelin injections for prostatic cancer presented with bilateral nodules in the lower abdominal wall. An excisional biopsy revealed a non-caseous epithelioid granuloma consisting of CD-68 positive histiocytic cells with infiltration of T-lymphocytes and eosinophils; skin metastasis from prostatic adenocarcinoma was ruled out through histological and immunohistochemical analysis. Generally, granulomas may be caused by delayed-type hypersensitivity to the constituents of leuprorelin acetate injections. |
| Databáze: | OpenAIRE |
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