Regression of esophageal varices and splenomegaly in two patients with hepatitis-C-related liver cirrhosis after interferon and ribavirin combination therapy
Autor: | Soon Jae Lee, Bong Soo Kim, Byung-Cheol Song, Seung Uk Jeong, Eun Kwang Choi, Sun Jin Boo, Hyung Joo Song, Yoo-Kyung Cho, Heung Up Kim, Soo-Young Na |
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Rok vydání: | 2016 |
Předmět: |
Liver Cirrhosis
Male 0301 basic medicine Cirrhosis Case Report medicine.disease_cause Gastroenterology Polyethylene Glycols chemistry.chemical_compound 0302 clinical medicine Esophageal varices Interferon Abdomen Endoscopy Digestive System Ultrasonography virus diseases Hepatitis C Middle Aged Recombinant Proteins Regression Hepatitis C Liver cirrhosis Drug Therapy Combination Female 030211 gastroenterology & hepatology medicine.drug medicine.medical_specialty Combination therapy Hepatitis C virus Esophageal and Gastric Varices Antiviral Agents 03 medical and health sciences Internal medicine Ribavirin medicine Humans In patient lcsh:RC799-869 Molecular Biology Hepatology business.industry Interferon-alpha medicine.disease 030104 developmental biology chemistry Splenomegaly lcsh:Diseases of the digestive system. Gastroenterology Tomography X-Ray Computed business |
Zdroj: | Clinical and Molecular Hepatology Clinical and Molecular Hepatology, Vol 22, Iss 3, Pp 390-395 (2016) |
ISSN: | 2287-285X 2287-2728 |
Popis: | Some recent studies have found regression of liver cirrhosis after antiviral therapy in patients with hepatitis C virus (HCV)-related liver cirrhosis, but there have been no reports of complete regression of esophageal varices after interferon/peg-interferon and ribavirin combination therapy. We describe two cases of complete regression of esophageal varices and splenomegaly after interferon-alpha and ribavirin combination therapy in patients with HCV-related liver cirrhosis. Esophageal varices and splenomegaly regressed after 3 and 8 years of sustained virologic responses in cases 1 and 2, respectively. To our knowledge, this is the first study demonstrating that complications of liver cirrhosis, such as esophageal varices and splenomegaly, can regress after antiviral therapy in patients with HCV-related liver cirrhosis. |
Databáze: | OpenAIRE |
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