Regression of esophageal varices and splenomegaly in two patients with hepatitis-C-related liver cirrhosis after interferon and ribavirin combination therapy

Autor: Soon Jae Lee, Bong Soo Kim, Byung-Cheol Song, Seung Uk Jeong, Eun Kwang Choi, Sun Jin Boo, Hyung Joo Song, Yoo-Kyung Cho, Heung Up Kim, Soo-Young Na
Rok vydání: 2016
Předmět:
Liver Cirrhosis
Male
0301 basic medicine
Cirrhosis
Case Report
medicine.disease_cause
Gastroenterology
Polyethylene Glycols
chemistry.chemical_compound
0302 clinical medicine
Esophageal varices
Interferon
Abdomen
Endoscopy
Digestive System
Ultrasonography
virus diseases
Hepatitis C
Middle Aged
Recombinant Proteins
Regression
Hepatitis C
Liver cirrhosis
Drug Therapy
Combination
Female
030211 gastroenterology & hepatology
medicine.drug
medicine.medical_specialty
Combination therapy
Hepatitis C virus
Esophageal and Gastric Varices
Antiviral Agents
03 medical and health sciences
Internal medicine
Ribavirin
medicine
Humans
In patient
lcsh:RC799-869
Molecular Biology
Hepatology
business.industry
Interferon-alpha
medicine.disease
030104 developmental biology
chemistry
Splenomegaly
lcsh:Diseases of the digestive system. Gastroenterology
Tomography
X-Ray Computed
business
Zdroj: Clinical and Molecular Hepatology
Clinical and Molecular Hepatology, Vol 22, Iss 3, Pp 390-395 (2016)
ISSN: 2287-285X
2287-2728
Popis: Some recent studies have found regression of liver cirrhosis after antiviral therapy in patients with hepatitis C virus (HCV)-related liver cirrhosis, but there have been no reports of complete regression of esophageal varices after interferon/peg-interferon and ribavirin combination therapy. We describe two cases of complete regression of esophageal varices and splenomegaly after interferon-alpha and ribavirin combination therapy in patients with HCV-related liver cirrhosis. Esophageal varices and splenomegaly regressed after 3 and 8 years of sustained virologic responses in cases 1 and 2, respectively. To our knowledge, this is the first study demonstrating that complications of liver cirrhosis, such as esophageal varices and splenomegaly, can regress after antiviral therapy in patients with HCV-related liver cirrhosis.
Databáze: OpenAIRE
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