Reducing the discomfort of lidocaine administration through pH buffering
| Autor: | Charles J. Tegtmeyer, John F. Angle, Andrew C. Reifsnyder, Alan H. Matsumoto, Gary D. Hartwell, J. Bayne Selby |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Lidocaine Adolescent Injections Intradermal Visual analogue scale medicine.drug_class medicine.medical_treatment Pain Buffers chemistry.chemical_compound Double-Blind Method Medicine Humans Radiology Nuclear Medicine and imaging Intradermal injection Prospective Studies Prospective cohort study Saline Sodium bicarbonate business.industry Local anesthetic Ph buffering Middle Aged Surgery Sodium Bicarbonate chemistry Anesthesia Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of vascular and interventional radiology : JVIR. 5(1) |
| ISSN: | 1051-0443 |
| Popis: | Purpose A prospective, double-blind study was undertaken to evaluate the effect of using a buffered lidocaine solution on the perception of pain experienced by a patient during its intradermal injection. Patients and Methods One hundred fifty patients undergoing diagnostic angiographic and interventional procedures at the authors’ institution were randomly assigned to receive a 1-mL aliquot of one of three lidocaine solutions: plain 1% lidocaine, 1% lidocaine diluted with normal saline in a 10:1 ratio, and 1% lidocaine diluted with 8.4% sodium bicarbonate in a 10:1 ratio. The lidocaine solutions were administered intradermally over 10–15 seconds. A numerical value was placed on the patient's perception of pain, separate from that associated with the 25-gauge needle insertion, with use of a linear visual analog scale. Results Mean pain scores were as follows: for the 1% lidocaine solution, 2.83 ± 2.60; for 1% lidocaine plus normal saline solution, 2.89 ± 2.34; and for 1% lidocaine plus sodium bicarbonate solution, 1.37 ± 1.73 ( P = .0018). Conclusion Buffering lidocaine significantly decreased the discomfort associated with its administration as a local anesthetic. |
| Databáze: | OpenAIRE |
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