Cause-specific mortality after a breast cancer diagnosis: a cohort study of 10,195 women in Girona and Tarragona
| Autor: | Alberto Ameijide, Maria Buxó, Marià Carulla, Rafael Marcos-Gragera, Ramon Clèries, Mireia Vilardell, Josep M. Borràs, J. A. Espinàs, M. L. Vilardell, Angel Izquierdo, Jaume Galceran, José Miguel Martínez |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Survival Cohort Studies 0302 clinical medicine Breast cancer Risk Factors Cause of Death Medicine Província) [Tarragona (Catalunya] Registries Cause of death Aged 80 and over education.field_of_study Incidence Absolute risk reduction Neoplasms Second Primary General Medicine Middle Aged Prognosis Survival Rate Oncology Estudi de casos Mama -- Càncer -- Mortalitat 030220 oncology & carcinogenesis Cohort Female Breast -- Cancer -- Mortality Cohort study Adult medicine.medical_specialty Adolescent Population Breast Neoplasms Càncer de mama Young Adult 03 medical and health sciences Diabetes mellitus Internal medicine Province) [Tarragona (Catalonia] Mortalitat Humans Mortality education Supervivència Aged business.industry Cancer medicine.disease Província) [Girona (Catalunya] 030104 developmental biology Spain Province) [Girona (Catalonia] Case studies business Follow-Up Studies |
| Zdroj: | Clinical and Translational Oncology, 2019, vol. 21, p. 1014-1025 Articles publicats (IdIBGi) DUGiDocs – Universitat de Girona instname Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | Evidence suggests an excess of long-term mortality due to cardiovascular diseases, second tumours and other causes in patients diagnosed with invasive breast cancer (BC). Our aim was to assess this risk of death in a cohort of patients diagnosed with BC in Girona and Tarragona, northeastern Spain. Materials and methods: Using data from the cancer registries in these areas, a population-based cohort study was carried out including all the women diagnosed with BC during 1985–2004 and followed up until December 31st 2014 (N = 10,195). The standardised mortality ratios (SMRs) were calculated for causes other than BC in the cohort at 10 years (periods 1985–1994/1995–2004) and 20 years (period 1985–1994). The impact of competing causes of death in the long-term survival was evaluated through competing risk analysis. Results: The SMRs at 10 and 20 years for all-cause mortality, except BC, were 1.21 and 1.22. The main causes of mortality showing statistically significant SMR at 10 years were other tumours (colon, lung, corpus uteri, ovary, and haematological), diabetes mellitus, diseases of the nervous system, cardiovascular diseases (after BC, the second competing cause of death among patients diagnosed > 69 years) and diseases of the kidney. Globally, the 10-year SMR was higher in the first period. After 20 years of follow-up (1985–1994 cohort), there were 48.5 excess deaths per 10,000 patient-years for causes other than BC. Conclusions: Women who did not die from BC at 10 or 20 years after the BC diagnosis had 20% higher risk of dying from other causes than women without BC. This excess risk must be clinically considered during 20 years after the BC diagnosis This work was supported by (1) Instituto deSalud Carlos III through the Project PI14/01041, co-funded by FEDER funds/European Regional Development Fund (ERDF)-a way to Build Europe-//FONDOS FEDER “una manera de hacer Europa” and by (2) Agència d’Avaluació d’Universitats i Recerca (2017SGR00735) from Generalitat de Catalunya |
| Databáze: | OpenAIRE |
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