Interleukin 35 (IL-35) and IL-37: Intestinal and peripheral expression by T and B regulatory cells in patients with Inflammatory Bowel Disease
| Autor: | Janette Furuzawa-Carballeda, Gabriela Fonseca-Camarillo, Jesús K. Yamamoto-Furusho |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Regulatory B cells Immunology Interleukin-3 Receptor alpha Subunit Gene Expression Inflammation CD8-Positive T-Lymphocytes Real-Time Polymerase Chain Reaction T-Lymphocytes Regulatory Biochemistry Inflammatory bowel disease Peripheral blood mononuclear cell Young Adult Crohn Disease medicine Humans Indoleamine-Pyrrole 2 3 -Dioxygenase Immunology and Allergy Intestinal Mucosa Molecular Biology Aged B-Lymphocytes Regulatory Crohn's disease business.industry Gene Expression Profiling Interleukins FOXP3 Hematology Middle Aged medicine.disease Interleukin-10 Cross-Sectional Studies Interleukin 35 Colitis Ulcerative Female medicine.symptom business CD8 Interleukin-1 |
| Zdroj: | Cytokine. 75:389-402 |
| ISSN: | 1043-4666 |
| Popis: | The aim of the study was to characterize and to quantify peripheral and tissue. IL-35- and IL-37-producing cells in Inflammatory Bowel Disease (IBD) patients. We studied a total of 38 active UC, 31 inactive UC, 17 active CD, and 13 inactive CD and 50 non-inflamed tissues as control group. Gene expression was measured by real time polymerase chain reaction (RT-PCR) and protein expression was evaluated in tissue by immunohistochemistry and in peripheral blood mononuclear cells by flow cytometry. Higher levels of IL-35 was produced by intestinal regulatory B cells and circulating regulatory CD4(+) and CD8(+) T cells in active vs. inactive disease or healthy donors (P |
| Databáze: | OpenAIRE |
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