Effects of N1-alkylnicotinamide chlorides on NADH oxidation in rat liver submitochondrial particles
| Autor: | Bruce M. Anderson, Burton J. Goodge |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Niacinamide
Pyridines Biophysics chemistry.chemical_element Mitochondria Liver In Vitro Techniques Photochemistry Biochemistry Chloride Medicinal chemistry Oxygen Electron Transport chemistry.chemical_compound medicine Animals Submitochondrial particle Ferricyanides Molecular Biology biology Chemistry Adenine Nucleotides NADH dehydrogenase Succinates NAD Electron transport chain Rats Rat liver biology.protein Ferricyanide medicine.drug |
| Zdroj: | Archives of biochemistry and biophysics. 140(1) |
| ISSN: | 0003-9861 |
| Popis: | Longer chain N 1 -alkylnicotinamide chlorides ( N 1 -octyl to N 1 -dodecyl, inclusive) were shown to be effective inhibitors of NADH oxidation in rat liver submitochondrial particles. A positive chainlength effect was observed in this inhibition. Inability of these compounds to inhibit succinate oxidation or NADH reduction of ferricyanide in these particles indicated a point of inhibition of the electron transport chain between the oxygen side of NADH dehydrogenase and the point at which electrons from succinate oxidation enter the chain. N 1 -Decyl-3-methylpyridinium chloride was synthesized and demonstrated to function in Submitochondrial particles in a similar fashion to that observed with N 1 -alkylnicotinamide chlorides. N 1 -Decyl-3-methylpyridinium chloride was approximately five times more effective as an inhibitor of NADH oxidation than was N 1 -decylnicotinamide chloride. |
| Databáze: | OpenAIRE |
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