Early predictors of abnormal MRI patterns in asphyxiated infants: S100B protein urine levels
| Autor: | Iliana Bersani, Giorgia Gasparroni, Moataza Bashir, Hanna Aboulgar, Hala Mufeed, Iman Iskander, Maria Kornacka, Darek Gruzfeld, Andrea Dotta, Francesca Campi, Daniela Longo, Immacolata Savarese, Annabella Braguglia, Lucia Gabriella Tina, Francesco Nigro, Laura Serpero, Maria Chiara Strozzi, Antonio Maconi, Patrizia Ianniello, Caterina Di Battista, Ebe D’Adamo, Danilo Gavilanes, Diego Gazzolo |
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| Přispěvatelé: | RS: GROW - R4 - Reproductive and Perinatal Medicine, RS: MHeNs - R3 - Neuroscience, Kindergeneeskunde, MUMC+: MA Medische Staf Kindergeneeskunde (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Asphyxia Neonatorum
SPECTROSCOPY PERINATAL ASPHYXIA hypoxic ischemic encephalopathy BIRTH Biochemistry (medical) Clinical Biochemistry BIOMARKERS Infant Newborn Reproducibility of Results ENCEPHALOPATHY General Medicine S100 Calcium Binding Protein beta Subunit brain damage Magnetic Resonance Imaging S100B BRAIN-DAMAGE Hypoxia-Ischemia Brain Humans hypothermia |
| Zdroj: | Clinical Chemistry and Laboratory Medicine, 60(11), 1745-1752. Walter de Gruyter GmbH |
| ISSN: | 1434-6621 |
| DOI: | 10.1515/cclm-2022-0559 |
| Popis: | Objectives The early detection and stratification of asphyxiated infants at higher risk for impaired neurodevelopment is challenging. S100B protein is a well-established biomarker of brain damage, but lacks conclusive validation according to the “gold standard” methodology for hypoxic-ischemic encephalopathy (HIE) prognostication, i.e. brain MRI. The aim of the present study was to investigate the predictive role of urinary S100B concentrations, assessed in a cohort of HIE infants receiving therapeutic hypothermia (TH), compared to brain MRI. Methods Assessment of urine S100B concentrations was performed by immunoluminometric assay at first void and at 4, 8, 12, 16, 20, 24, 48, 72, 96, 108 and 120-h after birth. Neurologic evaluation, routine laboratory parameters, amplitude-integrated electroencephalography, and cerebral ultrasound were performed according to standard protocols. Brain MRI was performed at 7–10 days of life. Results Overall, 74 HIE neonates receiving TH were included in the study. S100B correlated, already at first void, with the MRI patterns with higher concentrations in infants with the most severe MRI lesions. Conclusions High S100B urine levels soon after birth constitute trustable predictors of brain injury as confirmed by MRI. Results support the reliability of S100B in clinical daily practice and open the way to its inclusion in the panel of parameters used for the selection of cases suitable for TH treatment. |
| Databáze: | OpenAIRE |
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