Modulation of Antiviral Immunity by Heme Oxygenase-1
| Autor: | Janyra A. Espinoza, Alexis M. Kalergis, Pablo A. González |
|---|---|
| Přispěvatelé: | Le Bihan, Sylvie, Departamento de Microbiologıa y Genetica Molecular [Santiago, Chile] (Facultad de Ciencias Biologicas), Pontificia Universidad Católica de Chile (UC), Departamento de Endocrinología [Santiago, Chile] (Facultad de Medicina), Departamento de Ciencias Biologicas [Santiago, Chile] (Facultad de Ciencias Biologicas y Facultad de Medicina), Universidad Andrés Bello [Santiago] (UNAB), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Institut de transplantation urologie-néphrologie (ITUN), Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Hepatitis C virus viruses Heme Dengue virus Biology medicine.disease_cause Antiviral Agents Models Biological Virus Pathology and Forensic Medicine Microbiology 03 medical and health sciences medicine Animals Humans Antibody-dependent enhancement Hepatitis B virus Ebola virus [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology Immunity Virology 3. Good health Transplantation Heme oxygenase 030104 developmental biology Heme Oxygenase-1 [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | American Journal of Pathology American Journal of Pathology, 2017, 187 (3), pp.487-493. ⟨10.1016/j.ajpath.2016.11.011⟩ American Journal of Pathology, American Society for Investigative Pathology, 2017, 187 (3), pp.487-493. ⟨10.1016/j.ajpath.2016.11.011⟩ |
| ISSN: | 0002-9440 1525-2191 |
| DOI: | 10.1016/j.ajpath.2016.11.011⟩ |
| Popis: | International audience; Heme oxygenase-1 (HO-1) is a stress-inducible, anti-inflammatory, and cytoprotective enzyme expressed in most cell types in the organism. Under several stress stimuli, HO-1 expression and activity is up-regulated to catalyze the rate-limiting enzymatic step of heme degradation into carbon monoxide, free iron, and biliverdin. Besides its effects on cell metabolism, HO-1 is also capable of modulating host innate and adaptive immune responses in response to sepsis, transplantation, and autoimmunity, and preventing oxidative damage associated with inflammation. In addition, recent studies have reported that HO-1 can exert a significant antiviral activity against a wide variety of viruses, including HIV, hepatitis C virus, hepatitis B virus, enterovirus 71, influenza virus, respiratory syncytial virus, dengue virus, and Ebola virus, among others. Herein, we address the current understanding of the functional significance of HO-1 against a variety of viruses and its potential as a therapeutic strategy to prevent and control viral infections. Furthermore, we review the most important features of the immunoregu-latory functions for this enzyme. |
| Databáze: | OpenAIRE |
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