Genome-wide mapping and estimation of inbreeding depression of semen quality traits in a cattle population
| Autor: | Ino Curik, Johann Sölkner, Maja Ferenčaković, Miroslav Kapš |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male endocrine system Outbreeding depression Population Single-nucleotide polymorphism Biology Quantitative trait locus Runs of Homozygosity Polymorphism Single Nucleotide 03 medical and health sciences Semen quality Genetics Inbreeding depression Animals education Spermatogenesis reproductive and urinary physiology Insemination Artificial inbreeding depression sperm quality runs of homozygosity single nucleotide polymorphism 2. Zero hunger education.field_of_study Inbreeding Depression Sperm Count urogenital system Homozygote Chromosome Mapping Spermatozoa Semen Analysis 030104 developmental biology Austria Animal Science and Zoology Cattle Gene-Environment Interaction Inbreeding Food Science |
| Zdroj: | Journal of Dairy Science |
| ISSN: | 0022-0302 |
| DOI: | 10.3168/jds.2016-12164 |
| Popis: | Inbreeding depression is known to affect quantitative traits such as male fertility and sperm quality, but the genetic basis for these associations is poorly understood. Most studies have been limited to examining how pedigree- or marker-derived genome-wide autozygosity is associated with quantitative phenotypes. In this study, we analyzed possible associations of genetic features of inbreeding depression with percentage of live spermatozoa and total number of spermatozoa in 19, 720 ejaculates obtained from 554 Austrian Fleckvieh bulls during routine artificial insemination programs. Genome-wide inbreeding depression was estimated and genomic regions contributing to inbreeding depression were mapped. Inbreeding depression did affect total number of spermatozoa, and such depression was predicted by pedigree-based inbreeding levels and genome-wide inbreeding levels based on runs of homozygosity (ROH). Genome-wide inbreeding depression did not seem to affect percentage of live spermatozoa. A model incorporating genetic effects of the bull, environmental factors, and additive genetic and ROH status effects of individual single- nucleotide polymorphisms revealed genomic regions significantly associated with ROH status for total number of spermatozoa (4 regions) or percentage of live spermatozoa (5 regions). All but one region contains genes related to spermatogenesis and sperm morphology. These genomic regions contain genes affecting sperm morphogenesis and efficacy. The results highlight that next-generation sequencing may help explain some of the genetic factors contributing to inbreeding depression of sperm quality traits in Fleckvieh bulls. |
| Databáze: | OpenAIRE |
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