Dosimetric comparison of helical tomotherapy, intensity-modulated radiation therapy, volumetric-modulated arc therapy, and 3-dimensional conformal therapy for the treatment of T1N0 glottic cancer

Autor: Cemil Colak, Aysun Eraslan Fatma Eraslan, Bahaddin Yaprak, A. Altinok, N. Kucuk, Öztun Temelli, Kemal Ekici, Ozlem D. Alpak, Pelin Altinok Sut, Eda Kaya Pepele, Alpaslan Mayadagli
Přispěvatelé: ALTINOK SÜT, PELİN
Rok vydání: 2016
Předmět:
Glottis
medicine.medical_specialty
Ekici K.
Pepele E. K.
Yaprak B.
Ternelli O.
Eraslan A. F.
Kucuk N.
Altinok A. Y.
Sut P. A.
ALPAK O. D.
ÇOLAK C.
et al.
-Dosimetric comparison of helical tomotherapy
intensity-modulated radiation therapy
volumetric-modulated arc therapy
and 3-dimensional conformal therapy for the treatment of T1N0 glottic cancer-
Medical Dosimetry
cilt.41
ss.329-333
2016
genetic structures
medicine.medical_treatment
Planning target volume
Conformal Therapy
Tomotherapy
030218 nuclear medicine & medical imaging
Intensity-Modulated Radiotherapy
03 medical and health sciences
0302 clinical medicine
otorhinolaryngologic diseases
medicine
Humans
Radiology
Nuclear Medicine and imaging
Helical Tomotherapy
Laryngeal Neoplasms
Neoplasm Staging
Radiological and Ultrasound Technology
business.industry
Radiotherapy Planning
Computer-Assisted
Cancer
Radiotherapy Dosage
Intensity-modulated radiation therapy
medicine.disease
Larynx Cancer
Volumetric modulated arc therapy
Radiation therapy
Oncology
Glottic cancer
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Radiotherapy
Intensity-Modulated
Radiology
Volumetric Arc Therapy
Radiotherapy
Conformal
Nuclear medicine
business
therapeutics
Popis: Various radiotherapy planning methods for T1N0 laryngeal cancer have been proposed to decrease normal tissue toxicity. We compare helical tomotherapy (HT), linac-based intensity-modulated radiation therapy (IMRT), volumetric-modulated arc therapy (VMAT), and 3-D conformal radiotherapy (3D-CRT) techniques for T1N0 laryngeal cancer. Overall, 10 patients with T1N0 laryngeal cancer were selected and evaluated. Furthermore, 10 radiotherapy treatment plans have been created for all 10 patients, including HT, IMRT, VMAT, and 3D-CRT. IMRT, VMAT, and HT plans vs 3D-CRT plans consistently provided superior planning target volume (PTV) coverage. Similar target coverage was observed between the 3 IMRT modalities. Compared with 3D-CRT, IMRT, HT, and VMAT significantly reduced the mean dose to the carotid arteries. VMAT resulted in the lowest mean dose to the submandibular and thyroid glands. Compared with 3D-CRT, IMRT, HT, and VMAT significantly increased the maximum dose to the spinal cord It was observed that the 3 IMRT modalities studied showed superior target coverage with less variation between each plan in comparison with 3D-CRT. The 3D-CRT plans performed better at the Dmax of the spinal cord. Clinical investigation is warranted to determine if these treatment approaches would translate into a reduction in radiation therapy-induced toxicities. (C) 2016 American Association of Medical Dosimetrists.
Databáze: OpenAIRE
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