Serotonergic potentiation of dark pulse-induced phase-shifting effects at midday in hamsters
| Autor: | Daniel Clesse, Etienne Challet, Jorge E. Mendoza, Paul Pévet |
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| Přispěvatelé: | Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2008 |
| Předmět: |
Male
Agonist Serotonin endocrine system medicine.medical_specialty genetic structures medicine.drug_class [SDV]Life Sciences [q-bio] medicine.medical_treatment Motor Activity Biology Serotonergic Biochemistry Random Allocation 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cricetinae Internal medicine medicine Animals Circadian rhythm ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Mesocricetus Chronotherapy (sleep phase) Antagonist Darkness Circadian Rhythm Serotonin Receptor Agonists CLOCK Endocrinology nervous system Suprachiasmatic Nucleus sense organs Raphe nuclei Photic Stimulation 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurochemistry Journal of Neurochemistry, Wiley, 2008, 106 (3), pp.1404-1414. ⟨10.1111/j.1471-4159.2008.05493.x⟩ |
| ISSN: | 1471-4159 0022-3042 |
| Popis: | In mammals, resetting of the suprachiasmatic clock (SCN) by behavioral activation or serotonin (5-HT) agonists is mimicked by dark pulses, presented during subjective day in constant light (LL). Because behavioral resetting may be mediated in part by 5-HT inputs to the SCN, here we determined whether 5-HT system can modulate dark-induced phase-shifts in Syrian hamsters housed in LL. Two hours of darkness at mid-subjective day (circadian time 6; CT-6) resulted in increased concentrations of 5-HT in the SCN tissue and induction of c-FOS expression in the raphe nuclei. Injections of the 5-HT(1A/7) agonist +8-OH-DPAT or dark pulses at CT-6 induced phase-advances of the wheel-running activity rhythm and down-regulated the expression of the clock genes Per1-2 and c-FOS in the SCN in a similar way. The combination of both treatments [+8-OH-DPAT + dark pulses], however, resulted in larger phase-advances, while associated molecular changes were not significantly modified, except for the gene Dbp, in comparison to +8-OH-DPAT or dark pulses alone. Dark resetting was blocked by pre-treatment with a 5-HT(7) antagonist, but not with a 5-HT(1A) antagonist. The additive phase-shifts of two different cues to reset the SCN clock open wide the gateway for non-photic shifting, leading to new strategies in chronotherapy. |
| Databáze: | OpenAIRE |
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