| Autor: |
Eduardo Butturini de Carvalho, Ana Carolina Fernandes Fonseca, Raquel Ferreira Magalhães, Eliete Ferreira Pinto, Cynthia dos Santos Samary, Mariana Alves Antunes, Camila Machado Baldavira, Lizandre Keren Ramos da Silveira, Walcy Rosolia Teodoro, Marcelo Gama de Abreu, Vera Luiza Capelozzi, Nathane Santanna Felix, Paolo Pelosi, Patrícia Rieken Macêdo Rocco, Pedro Leme Silva |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Physiological Reports. 10 |
| ISSN: |
2051-817X |
| Popis: |
Optimal fluid management is critical during mechanical ventilation to mitigate lung damage. Under normovolemia and protective ventilation, pulmonary tensile stress during pressure-support ventilation (PSV) results in comparable lung protection to compressive stress during pressure-controlled ventilation (PCV) in experimental acute lung injury (ALI). It is not yet known whether tensile stress can lead to comparable protection to compressive stress in ALI under a liberal fluid strategy (LF). A conservative fluid strategy (CF) was compared with LF during PSV and PCV on lungs and kidneys in an established model of ALI. Twenty-eight male Wistar rats received endotoxin intratracheally. After 24 h, they were treated with CF (minimum volume of Ringer's lactate to maintain normovolemia and mean arterial pressure ≥70 mmHg) or LF (~4 times higher than CF) combined with PSV or PCV (V |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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