Dependence of Generation of Hippocampal CA1 Slow Oscillations on Electrical Synapses
| Autor: | Lidan Wang, Zhiru Wang, Yuan Xu, Ying-Wei Wang, Yu-zhang Liu, Feng-Yan Shen |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Physiology Carbenoxolone Hippocampus Action Potentials Hippocampal formation Synaptic Transmission Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Electrical Synapses medicine Animals Electrical synapse CA1 Region Hippocampal Ion channel Neurons Oscillation Chemistry General Neuroscience Pyramidal Cells Gap junction Gap Junctions General Medicine Rats Mefloquine 030104 developmental biology medicine.anatomical_structure nervous system Inhibitory Postsynaptic Potentials Synapses Original Article Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurosci Bull |
| ISSN: | 1995-8218 |
| Popis: | Neuronal oscillations in the hippocampus are critical for many brain functions including learning and memory. The underlying mechanism of oscillation generation has been extensively investigated in terms of chemical synapses and ion channels. Recently, electrical synapses have also been indicated to play important roles, as reported in various brain areas in vivo and in brain slices. However, this issue remains to be further clarified, including in hippocampal networks. Here, using the completely isolated hippocampus, we investigated in vitro the effect of electrical synapses on slow CA1 oscillations (0.5 Hz–1.5 Hz) generated intrinsically by the hippocampus. We found that these oscillations were totally abolished by bath application of a general blocker of gap junctions (carbenoxolone) or a specific blocker of electrical synapses (mefloquine), as determined by whole-cell recordings in both CA1 pyramidal cells and fast-spiking cells. Our findings indicate that electrical synapses are required for the hippocampal generation of slow CA1 oscillations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12264-019-00419-z) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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