Beneficial effects of Cinnamon on hepatic lipid metabolism are impaired in hypothyroid rats
| Autor: | Gabriela S. M. Paula, Georgia C. Atella, Bruna Pereira Lopes, Karen Jesus Oliveira, Carmen C. Pazos-Moura, Luana L. Souza, George Eduardo Gabriel Kluck, Thaiane Gadioli Gaique |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty endocrine system diseases Medicine (miscellaneous) 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Hypothyroidism Internal medicine Hyperlipidemia medicine Ingestion TX341-641 Euthyroid Beneficial effects Nutrition and Dietetics Nutrition. Foods and food supply business.industry Cinnamon Lipid metabolism Metabolism medicine.disease Cinnamomum zeylanicum 030104 developmental biology Endocrinology Liver Hepatic lipid Rat business hormones hormone substitutes and hormone antagonists Food Science |
| Zdroj: | Journal of Functional Foods, Vol 50, Iss, Pp 210-215 (2018) |
| ISSN: | 1756-4646 |
| Popis: | Hypolipidemic effects of cinnamon (Cinnamomum zeylanicum) have been described in humans and in experimental animals. Hypothyroidism is frequently associated with hyperlipidemia. Here we investigated the effects of chronic ingestion of cinnamon on lipid metabolism of hypothyroid male Wistar rats. Rats received methimazole for 7 weeks, and treated either with cinnamon as powder added to the chow or aqueous extract of cinnamon, during the last 4 weeks of protocol, and compared to untreated hypothyroid and euthyroid rats. Cinnamon intake reduced body mass increasing fat mass and reducing body protein content of hypothyroid rats. Cinnamon ingestion did not revert the hypercholesterolemia of hypothyroid rats and promoted a further reduction in serum T3, suggesting a worsening of the hypothyroid condition. Our results indicate that the beneficial effects of cinnamon on lipid metabolism are impaired in hypothyroidism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect