Total Synthesis of Cladoniamide G
| Autor: | Raymond J. Andersen, Benjamin Loosley, Gregory R. Dake |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Carbamate
Lactams Lichens Stereochemistry medicine.medical_treatment Antineoplastic Agents Breast Neoplasms Oxidative phosphorylation Biochemistry Indole Alkaloids chemistry.chemical_compound medicine Humans Cladoniamide G Cytotoxic T cell Physical and Theoretical Chemistry Molecular Structure Tandem Chemistry Organic Chemistry Total synthesis Streptomyces MCF-7 Cells Lactam Carbamates Breast cancer cells Drug Screening Assays Antitumor Oxidation-Reduction |
| Zdroj: | Organic Letters. 15:1152-1154 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol400055v |
| Popis: | The total synthesis of cladoniamide G, a cytotoxic compound against MCF-7 breast cancer cells (10 μg/mL), was accomplished. Key steps in the sequence include oxidative dimerization of 3-acetoxy-5-chloroindole and a tandem process incorporating three steps: bimolecular carbonyl addition, lactam formation, and carbamate removal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|