Eradication of Helicobacter pylori infection in patients with non-ulcer dyspepsia : Effects on basal and bombesin-stimulated serum gastrin and gastric acid secretion
| Autor: | Jan B.M.J. Jansen, M. L. Verhulst, Albert Tangerman, Wim P.M. Hopman |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Biology Group A Gastroenterology Group B Nutrition secretion and motility Helicobacter Infections Gastric Acid chemistry.chemical_compound Basal (phylogenetics) Internal medicine Voeding secretie en motoriek Gastrins medicine Humans Dyspepsia GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Gastrin Helicobacter pylori Stomach Bombesin Middle Aged biology.organism_classification medicine.anatomical_structure Endocrinology chemistry Gastric Mucosa Gastric acid Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | Scandinavian Journal of Gastroenterology, 30, 968-973 Scandinavian Journal of Gastroenterology, 30, 10, pp. 968-973 Scandinavian Journal of Gastroenterology, 30, pp. 968-973 |
| ISSN: | 0036-5521 |
| Popis: | This study evaluates the effect of eradicating Helicobacter pylori on basal and bombesin-stimulated gastric acid secretion and serum gastrin in non-ulcer dyspepsia.Before and 1 month after an attempt to eradicate H. pylori basal and bombesin-stimulated gastric acid outputs were measured in 23 patients. H. pylori was eradicated in 15 patients (group A) but not in the other 8 (group B). Incremental gastric acid output was calculated by subtracting basal from bombesin-stimulated values.Basal acid output increased significantly (p = 0.01) after therapy in group A (delta 1.6 +/- 0.6 mmol/h) but not in group B (delta 0.2 +/- 0.5 mmol/h). Incremental gastric acid output decreased distinctly (delta-3.9 +/- 1.4 mmol/h) after therapy in group A (p = 0.02) but not in group B (delta-2.2 +/- 1.7 mmol/h). Basal serum gastrin decreased significantly (p0.005) after therapy in group A (delta-9 +/- 4 pM) but not in group B (delta-1 +/- 2 pM). Integrated serum gastrin responses to bombesin decreased markedly (p0.001) after therapy in group A (delta-5.0 +/- 1.6 nM*60 min) but slightly in group B (delta-0.9 +/- 1.3 nM*60 min) (p0.05).In patients with non-ulcer dyspepsia basal serum gastrin concentrations decrease but basal gastric acid outputs increase after eradication of H. pylori. Bombesin-induced increments in gastric acid output, however, decrease in parallel with gastrin release. |
| Databáze: | OpenAIRE |
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