BNP as marker of heart dysfunction in patients with liver cirrhosis
| Autor: | G. Solórzano, Juan A. Vallejo, Javier Padillo, Jordi Muntané, Pilar Rioja, Ruben Ciria, Manuel de la Mata, MC Muñoz-Villanueva, Antonio Sitges-Serra |
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| Rok vydání: | 2010 |
| Předmět: |
Cardiac function curve
Adult Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Heart Diseases medicine.drug_class Radionuclide ventriculography Blood Pressure Severity of Illness Index Liver disease Model for End-Stage Liver Disease Heart Rate Predictive Value of Tests Internal medicine Dobutamine Natriuretic Peptide Brain medicine Natriuretic peptide Humans Longitudinal Studies Prospective Studies Radionuclide Ventriculography Ejection fraction Hepatology business.industry Gastroenterology Stroke Volume Middle Aged medicine.disease Endocrinology Spain Multivariate Analysis cardiovascular system Cardiology Female business Atrial Natriuretic Factor Biomarkers medicine.drug |
| Zdroj: | European journal of gastroenterologyhepatology. 22(11) |
| ISSN: | 1473-5687 |
| Popis: | Backgrounds Patients with liver cirrhosis suffer various degrees of cardiac dysfunction which may be crucial in determining the outcome of surgery. The aim of this study was to determine the role of natriuretic peptides on the assessment of cardiac dysfunction in patients with liver cirrhosis. Methods Prospective longitudinal study of 30 patients with hepatic cirrhosis. Severity of disease was assessed according to the Child-Turcotte-Pugh and Model for End Stage Liver Disease (MELD) scores. Cardiac function was assessed using endocrine markers [atrial natriuretic peptide-brain natriuretic peptide (BNP)] and isotopic ventriculography at baseline and after stimulation with dobutamine. Results The ejection fraction was higher in patients with Child A+B and MELD less than 18 than in patients with advanced liver disease. A significant correlation between BNP plasma levels and MELD values was observed. Dobutamine induced a marked improvement in myocardial performance associated to a decrease in BNP levels. Multivariate analysis showed that BNP has prognostic value as a marker of cardiac ejection fraction. Patients whose baseline BNP concentrations were more than 70 pg/ml had an ejection fraction of around 45%. Conclusion This study has shown that increased baseline BNP concentrations may be regarded together with high Child and MELD scores, as the critical cardiac dysfunction threshold in cirrhotic patients. |
| Databáze: | OpenAIRE |
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