Peptides as tools and drugs for immunotherapies
| Autor: | Thien Ngoc Nguyen, Marie-Claire Bussat, Thierry Champion, Thierry Wurch, Jean-François Haeuw, Alain Beck, Liliane Goetsch, Christine Klinguer-Hamour, Alain Milon, Alain Van Dorsselaer, Nathalie Corvaia, Masae Sugawara |
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| Rok vydání: | 2007 |
| Předmět: |
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Molecular medicine.drug_class Molecular Sequence Data Epitopes T-Lymphocyte Monoclonal antibody Cancer Vaccines Peptide Mapping Biochemistry Melanoma Vaccine Virus Mice Immune system Structural Biology Drug Discovery Respiratory Syncytial Virus Vaccines medicine Animals Humans Subunit vaccines Amino Acid Sequence Antigens Viral Molecular Biology Pharmacology biology Chemistry Organic Chemistry Models Immunological Antibodies Monoclonal General Medicine Clinical trial Epitope mapping Respiratory Syncytial Virus Human Immunology biology.protein Epitopes B-Lymphocyte Molecular Medicine Immunotherapy Antibody Peptides |
| Zdroj: | Journal of Peptide Science. 13:588-602 |
| ISSN: | 1099-1387 1075-2617 |
| DOI: | 10.1002/psc.852 |
| Popis: | Peptides are essential tools for discovery and pre-clinical and pharmaceutical development of viral and cancer vaccines (‘active immunotherapies’) as well as for therapeutic antibodies (‘passive immunotherapies’). They help to trigger and analyze immune responses at a molecular level (B-cell, T-helper and CTL epitopes). They contribute largely to the design of new vaccine candidates and to the generation of monoclonal antibodies. They are also valuable analytical reference compounds for the structural characterisation by liquid chromatography and mass spectrometry of recombinant proteins used as biopharmaceuticals. As for other therapeutic applications, formulation, solubilisation, batch consistency and stability, issues have to be addressed to allow the pre-clinical and clinical development of this class of compounds as immunotherapeutic drugs. In the present review, three case studies dealing with (i) the design and the characterisation of Respiratory Syntycial Virus subunit vaccines, (ii) peptide-based melanoma vaccines, and (iii) therapeutic monoclonal antibodies, all investigated in clinical trials, are reported and discussed. Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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