Acyclovir Achieves a Lower Concentration in African HIV-Seronegative, Herpes Simplex Virus 2-Seropositive Women than in Non-African Populations
| Autor: | James P. Hughes, Yanhui Lu, Stewart E Reid, Anna Wald, Connie Celum, Frances M. Cowan, Craig W. Hendrix, Sinead Delany-Moretlwe, Lawrence Corey, Jared M. Baeten, Ellen Wilcox |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Zimbabwe Adolescent Herpesvirus 2 Human viruses Human immunodeficiency virus (HIV) Acyclovir Administration Oral Biological Availability Black People Zambia Clinical Therapeutics Biology medicine.disease_cause Antiviral Agents Peak concentration South Africa Pharmacokinetics HIV Seronegativity medicine Humans Pharmacology (medical) Dna viral Herpes Genitalis Pharmacology virus diseases Genitalia Female Middle Aged Virology Genital ulcer Infectious Diseases Herpes simplex virus Area Under Curve DNA Viral Female medicine.symptom |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 56:2777-2779 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.06160-11 |
| Popis: | Acyclovir pharmacokinetics was evaluated in 68 HIV-seronegative, herpes simplex virus 2 (HSV-2)-seropositive African women, who received a single oral 400-mg dose of acyclovir, with plasma acyclovir concentrations measured over 8 h. Geometric mean peak concentration and area under the concentration-time curve were 0.31 μg/ml and 1.59 h · μg/ml, respectively, 54% and 52% lower than values from non-Africans. Lower acyclovir concentrations may partly explain the reduced acyclovir suppression of HSV-2 genital ulcer recurrence in HPTN 039 African women participants. |
| Databáze: | OpenAIRE |
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