Prevalence of growth hormone (GH) deficiency in previously GH-treated young adults with Prader-Willi syndrome

Autor: Gera Hoorweg-Nijman, Anita C. S. Hokken-Koelega, Martijn J. J. Finken, Mariette van Leeuwen, Stephany Donze, Gianni Bocca, Petr E. Jira, Janiëlle A E M van Alfen-van der Velden, Layla Damen
Přispěvatelé: Pediatrics, Pediatric surgery, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Reproduction & Development (AR&D), Other Research
Rok vydání: 2019
Předmět:
growth hormone deficiency
medicine.medical_specialty
BODY-COMPOSITION
Endocrinology
Diabetes and Metabolism
030209 endocrinology & metabolism
CHILDREN
Prader‐Willi syndrome
Growth hormone
DIAGNOSIS
THERAPY
Growth hormone deficiency
RESPONSIVENESS
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
0302 clinical medicine
Endocrinology
Internal medicine
medicine
growth hormone-releasing hormone
Endocrine system
growth hormone‐releasing hormone
ENDOCRINE
Young adult
IGF‐I
Paediatric Endocrinology
ARGININE
business.industry
Significant difference
Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16]
nutritional and metabolic diseases
Growth hormone–releasing hormone
medicine.disease
IGF-I
030220 oncology & carcinogenesis
growth hormone
SECRETION
COGNITION
Original Article
ORIGINAL ARTICLES
Prader-Willi syndrome
business
GH Deficiency
Hormone
Zdroj: Clinical Endocrinology, 91(1), 118-123. Wiley
Clinical Endocrinology, 91, 118-123
Clinical Endocrinology, 91, 1, pp. 118-123
Clinical Endocrinology, 91(1), 118-123. Wiley-Blackwell Publishing Ltd
Donze, S H, Damen, L, van Alfen-van der Velden, J A E M, Bocca, G, Finken, M J J, Hoorweg-Nijman, G J G, Jira, P E, van Leeuwen, M & Hokken-Koelega, A C S 2019, ' Prevalence of growth hormone (GH) deficiency in previously GH-treated young adults with Prader-Willi syndrome ', Clinical Endocrinology, vol. 91, no. 1, pp. 118-123 . https://doi.org/10.1111/cen.13988
Clinical Endocrinology
Clinical Endocrinology, 91(1), 118-123. Wiley-Blackwell
ISSN: 0300-0664
DOI: 10.1111/cen.13988
Popis: OBJECTIVE: Some features of subjects with Prader-Willi syndrome (PWS) resemble those seen in growth hormone deficiency (GHD). Children with PWS are treated with growth hormone (GH), which has substantially changed their phenotype. Currently, young adults with PWS must discontinue GH after attainment of adult height when they do not fulfil the criteria of adult GHD. Limited information is available about the prevalence of GHD in adults with PWS. This study aimed to investigate the GH/insulin-like growth factor (IGF-I) axis and the prevalence of GHD in previously GH-treated young adults with PWS.DESIGN: Cross-sectional study in 60 young adults with PWS.MEASUREMENTS: Serum IGF-I and IGFBP-3 levels, GH peak during combined growth hormone-releasing hormone (GHRH)-arginine stimulation test.RESULTS: Serum IGF-I was CONCLUSIONS: In a large group of previously GH-treated young adults with PWS, approximately 1 in 7 exhibited a GH peak
Databáze: OpenAIRE
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