Impacto de la Fortificación con Ácido Fólico Sobre el Estado Nutricional en Mujeres y la Prevalencia de Defectos del Tubo Neural
| Autor: | Ana Biglieri, Elvira B Calvo |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Revista chilena de pediatría v.81 n.1 2010 SciELO Chile CONICYT Chile instacron:CONICYT Revista chilena de pediatría, Volume: 81, Issue: 1, Pages: 78-79, Published: FEB 2010 |
| Popis: | Impact of folic acid fortification on women nutritional status and on the prevalence of neural tube defects Introduction: In 2003 iron and folic acid fortification of wheat flour became mandatory in Argentina. Folate nutritional status was assessed in a national probabilistic sample of women 10-49 years old and pregnant women. Changes in the prevalence of neural tube defects (NTDs) were evaluated before and after fortification. Population and Methods: Data from the National Nutritional and Health Survey done in 2005 were used for folate intakes (24 h dietary recall) and serum levels. Fetal and infant mortality rates for NTDs were assessed in the period 2000-2006 from Vital Statistics Series, based on birth and death certificates. Prevalence of NTDs in hospital discharge statistics were analyzed in the pre and post fortification period. Results: Median folate in-takes were 532 and 821 µg/ day in women 10-49 years-old and pregnant women, respectively. In both groups, folic acid from wheat flour represented 245 and 331 µg/day. Serum folate was assessed in 5,322 women 10-49 years old and in 1,321 pregnant women. Prevalence of serum folate concentration < 3 ng/mL was 0.8% in women of child-bearing age and 2.7% in pregnant women. Mortality rate due to anencephaly in 2000-2003 was 53.1 per 100.000 births and decreased to 23.3 per 100.000 births in 2005-2006. Spina bifida mortality rate decreased 67% in the same period. In a similar way, hospital discharge statistics showed a decrease of 54% for anencephaly, 33% for encephalocele, and 45% for spina bifida between 2000 and 2005. Conclusions: Food fortification with folic acid was associated with adequate intakes and serum folate levels in women. Concur-rently, NTDs prevalence and mortality showed a significant reduction. (Key words: Folic acid, neural tube defects, intake, serum folate, Vitamin B12). Arch Argent Pediatr 2008; 106 (6): 492-498/492RESUMENIntroduccion: Se evaluo el efecto de la fortificacion de la harina de trigo con acido folico (iniciada en 2003) sobre la ingesta de folatos en la poblacion de mujeres en edad reproductiva y en embarazadas y los niveles sericos de folato y vitamina B12 en los mismos grupos. Asimismo, se analizaron los cambios ocurridos en CONO SURRev Chil Pediatr 2010; 81 (1): 78-79SOUTH CONE OF AMERICA |
| Databáze: | OpenAIRE |
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