Elucidation of Antifungal Metabolites Produced by Pseudomonas aurantiaca IB5-10 with Broad-Spectrum Antifungal Activity
| Autor: | Sang Dal Kim, Jong Hui Lim, Sang Hee Shim, Gwee Kyo Park |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Antifungal Agents
biology Metabolite Pseudomonas Fungi food and beverages Microbial Sensitivity Tests General Medicine biology.organism_classification Applied Microbiology and Biotechnology Pythium ultimum Microbiology Rhizoctonia solani chemistry.chemical_compound Phytophthora capsici chemistry Pseudomonas aurantiaca Pseudomonadales Phenazines Plant Diseases Biotechnology Pseudomonadaceae |
| Zdroj: | Journal of Microbiology and Biotechnology. 22:326-330 |
| ISSN: | 1738-8872 1017-7825 |
| DOI: | 10.4014/jmb.1106.06042 |
| Popis: | Antifungal metabolites were isolated from a culture of Pseudomonas aurantiaca IB5-10. Chemical structures of the metabolites were elucidated as phenazine-1-carboxylic acid (PCA; 1), 2-hydroxyphenazine (2-OH-PHZ; 2), and cyclo-(L-Pro-L-Val; 3), respectively, based on spectroscopic methods. Among them, 3 was isolated for the first time from this strain. The antifungal activities of 1-3 were evaluated against a variety of plant pathogens. To the best of our knowledge, the antifungal activities of 3 against plant fungal pathogens have been evaluated for the first time in this work. PCA (1) showed the most potent antifungal activities against Phytophthora capsici, Rhizoctonia solani AG-1(IA), and Pythium ultimum with MICs (microgram/ml) of less than 1.0, 1.3, and 2.0, respectively. On the other hand, 2-OH-PHZ (2) showed potent antifungal activity against R. solani AG-1(IA) with the MIC (microgram/ml) of 2.0, whereas it showed moderate antifungal activity against P. ultimum with the MIC (microgram/ml) of 50.0. In addition, 3 showed antifungal activity against only R. solani AG- 1(IA). |
| Databáze: | OpenAIRE |
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