Notch signaling pathway mediates alveolar bone resorption in apical periodontitis
| Autor: | Miroslav Andric, Katarina Beljic-Ivanovic, Maja Miletic, Jelena Milasin, Nadja Nikolic, Aleksandar Jakovljevic |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Alveolar Bone Loss Notch signaling pathway Inflammation Biology Bone and Bones Bone resorption Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Receptor Cell Proliferation Periodontitis Receptors Notch RANK Ligand General Medicine medicine.disease 3. Good health Resorption Cell biology 030104 developmental biology Cytokines Signal transduction medicine.symptom Periapical Periodontitis 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Medical Hypotheses |
| ISSN: | 0306-9877 |
| DOI: | 10.1016/j.mehy.2019.02.018 |
| Popis: | Apical periodontitis represents a chronic inflammatory process within periapical tissues, mostly caused by etiological agents of endodontic origin. Progressive bone resorption in the periapical region represents the hallmark of apical periodontitis and occurs as the consequence of interplay between polymicrobial infections and host response. The Notch signaling pathway is an evolutionary conserved cell-signaling system that plays an important role in a variety of cell functions including proliferation, differentiation and apoptosis. In recent years its involvement in bone homeostasis has attracted a significant consideration. We hypothesized that Notch signaling pathway, which has a complex interplay with proinflammatory cytokines and bone resorption regulators, contributes to alveolar bone resorption via increased Notch receptors on immune cell surface and stimulates Notch receptor intracellular domain (NICD) translocation into the nucleus. The potential benefit of medications aimed to down-regulate these pathways in apical periodontitis treatment remains to be assessed. |
| Databáze: | OpenAIRE |
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