Citrus Peel Flavonoids as Potential Cancer Prevention Agents
| Autor: | Balakrishnan Shammugasamy, Fariba Dehghani, Peter Valtchev, Qihan Dong, Aaron Schindeler, Nooshin Koolaji |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Flavonoid citrus peel extract Medicine (miscellaneous) Review Biology anticancer 03 medical and health sciences AcademicSubjects/MED00060 0302 clinical medicine medicine chemistry.chemical_classification Nutrition and Dietetics Cancer prevention Cell growth fungi apoptosis food and beverages Cell cycle In vitro 030104 developmental biology chemistry Mechanism of action Biochemistry Polyphenol inflammation 030220 oncology & carcinogenesis flavonoids medicine.symptom Food Science Citrus fruit mechanism of action |
| Zdroj: | Current Developments in Nutrition |
| ISSN: | 2475-2991 |
| Popis: | Citrus fruit and in particular flavonoid compounds from citrus peel have been identified as agents with utility in the treatment of cancer. This review provides a background and overview regarding the compounds found within citrus peel with putative anticancer potential as well as the associated in vitro and in vivo studies. Historical studies have identified a number of cellular processes that can be modulated by citrus peel flavonoids including cell proliferation, cell cycle regulation, apoptosis, metastasis, and angiogenesis. More recently, molecular studies have started to elucidate the underlying cell signaling pathways that are responsible for the flavonoids’ mechanism of action. These growing data support further research into the chemopreventative potential of citrus peel extracts, and purified flavonoids in particular. This critical review highlights new research in the field and synthesizes the pathways modulated by flavonoids and other polyphenolic compounds into a generalized schema. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|