The association of heat shock protein genetic polymorphisms with age-related hearing impairment in Taiwan
| Autor: | Wen-Yi Lin, Chen-Yu Chien, Hua-Ling Yang, Meng-Hsuen Hsieh, Chia-Yen Dai, Kuen-Yao Ho, Ning-Chia Chang |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Oncology Aging medicine.medical_specialty Age-related hearing impairment Genotype RD1-811 Taiwan Single-nucleotide polymorphism Polymorphism Single Nucleotide HSPA1B 03 medical and health sciences 0302 clinical medicine Asian People Internal medicine Age related Heat shock protein medicine Humans Genetic Predisposition to Disease HSP70 Heat-Shock Proteins Original Research Article HSPA1L Allele Hearing Loss 030223 otorhinolaryngology Alleles Aged Aged 80 and over business.industry Haplotype Single nucleotide polymorphism Otorhinolaryngology Case-Control Studies Female Surgery business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Otolaryngology-Head and Neck Surgery, Vol 50, Iss 1, Pp 1-7 (2021) Journal of Otolaryngology-Head & Neck Surgery |
| ISSN: | 1916-0216 |
| Popis: | Background Age-related hearing impairment (ARHI) is a major disability among the elderly population. Heat shock proteins (HSPs) were found to be associated with ARHI in animal studies. The aim of this study was to analyze the associations of single nucleotide polymorphisms (SNPs) of HSP genes with ARHI in an elderly population in Taiwan. Methods Participants ≥65 years of age were recruited for audiometric tests and genetic analyses. The pure tone average (PTA) of the better hearing ear was calculated for ARHI evaluation. The associations of HSPA1L (rs2075800 and rs2227956), HSPA1A (rs1043618) and HSPA1B (rs2763979) with ARHI were analyzed in 146 ARHI-susceptible (cases) and 146 ARHI-resistant (controls) participants. Results The “T” allele of HSPA1B rs2763979 showed a decreased risk of ARHI. The “TT” genotype of rs2763979 also showed a decreased risk of ARHI in the dominant hereditary model. For HSPA1L (rs2075800 and rs2227956) and HSPA1A (rs1043618), the haplotype “CAG” was related to a decreased risk of ARHI. Conclusion These findings suggest that HSP70 polymorphisms are associated with susceptibility to ARHI in the elderly population. Graphical abstract |
| Databáze: | OpenAIRE |
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