Novel Role of Vitamin K2: A Potent Inducer of Differentiation of Various Human Myeloid Leukemia Cell Lines
| Autor: | S Hashimoto, T. Hida, Shigemitsu Ohsawa, I. Sakai, M. Yoda, Shigeo Nakajo, Kazuyasu Nakaya |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Vitamin K
Cellular differentiation Population Biophysics Retinoic acid Biology Biochemistry Cell Line chemistry.chemical_compound Leukemia Promyelocytic Acute Differentiation therapy Tumor Cells Cultured medicine Humans education Molecular Biology education.field_of_study Dose-Response Relationship Drug Vitamin K2 Myeloid leukemia Cell Differentiation Vitamin K 1 Cell Biology Molecular biology Kinetics chemistry Leukemia Myeloid Cell culture Camptothecin medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 205:1305-1310 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1994.2807 |
| Popis: | When myeloblastic ML1 cells were cultured in the presence of Vitamin K 2 (menaquinone, VK 2 ), the population of cells capable of reducing NBT increased to 83.5% at low VK 2 concentration of 1 μM, indicating VK 2 induces cellular differentiation. VK 2 also exerted differentiation-inducing action on histiocytic U937 and promyelocytic HL60 cell lines. None of these effects were observed with Vitamin K 1 (phylloquinone, VK 1 ), suggesting the geranylgeranyl group of the side chain of VK 2 to be essential to these effects. Combinations of VK 2 with other differentiation-inducers such as interferon-γ retinoic acid, or camptothecin additively or synergistically induced the differentiation of HL-60 cells. These results suggest that VK 2 may safely be used in differentiation therapy in combination with other inducers. |
| Databáze: | OpenAIRE |
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