Local siRNA delivery by non-viral vectors

Autor:	Mathieu Mével, Fanny Beilvert, B. Châtin, Bruno Pitard
Rok vydání:	2012
Předmět:	Conjugated siRNA Mucosal Small interfering RNA business.industry Intratumoral Intraocular Intracerebral Systemic injection Pharmaceutical Science Pharmacology Article Viral vector Cationic lipid Local RNA interference siRNA Cancer research Medicine Polymer Local injection business Delivery
Zdroj:	Journal of Drug Delivery Science and Technology
ISSN:	1773-2247
DOI:	10.1016/s1773-2247(12)50002-x
Popis:	Since the discovery of the RNA interference (RNAi) phenomenon, RNAi-based therapies now present a huge potential for the treatment of many diseases, including inflammatory and infectious diseases and cancers. While numerous reports have described the development of small interfering RNA (siRNA) delivery systems for in-vivo applications, only a small number of siRNA-based therapies are currently under clinical development. This is essentially due to the lack of efficient and safe siRNA delivery systems for intravenous administration. However, the delivery of siRNA after local injection could represent an attractive route of administration to limit the issues of toxicity associated with systemic injection. We will describe here the different synthetic vectors which have been developed for the local delivery of siRNA in various organs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55206a2ff75f5b1cf5165d0fd279e267 https://doi.org/10.1016/s1773-2247(12)50002-x Zobrazit plný text záznamu Full Text from ScienceDirect