Topical delivery of acyclovir and ketoconazole
| Autor: | Lizelle T. Fox, Gerda A. Jacobs, Jan L. du Preez, Jeanetta du Plessis, Maides M. Malan, Minja Gerber |
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| Přispěvatelé: | 10065318 - Du Plessis, Jeanetta, 11329025 - Gerber, Minja, 10060510 - Du Preez, Jan Lourens, 10187243 - Malan, Maides Maria, 12815268 - Fox, Lizelle Trifena |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Antifungal Agents
Tape stripping Nitrous Oxide Human immunodeficiency virus (HIV) Acyclovir Pharmaceutical Science 02 engineering and technology Pharmacology medicine.disease_cause 030226 pharmacology & pharmacy Diffusion Ointments 0302 clinical medicine Drug Stability Skin media_common Transdermal Drug Carriers Viscosity Fatty Acids General Medicine Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Ketoconazole medicine.anatomical_structure Topical delivery Female Delivery system 0210 nano-technology Stability medicine.drug Drug Franz cell medicine.medical_specialty Drug Compounding Drug Storage Skin Absorption media_common.quotation_subject In Vitro Techniques Administration Cutaneous Antiviral Agents Pheroid™ 03 medical and health sciences Stratum corneum medicine Humans Technology Pharmaceutical Particle Size business.industry Dermatology Solubility business Gels |
| Popis: | Context: Viral and fungal cutaneous manifestations are regularly encountered in immunocompromised HIV/AIDS individuals and can be treated by drugs such as acyclovir and ketoconazole, respectively. Objective: The aim of this study was to determine whether the novel Pheroid™ delivery system improved the transdermal delivery and/or dermal delivery of acyclovir and ketoconazole when incorporated into semi-solid formulations. Materials and methods: Semi-solid products (creams and emulgels) containing these drug compounds were formulated, either with or without (control) the Pheroid™ delivery system. The stability of the formulated semi-solid products was examined over a period of six months and included the assay of the actives, pH, viscosity, mass loss and particle size observation. Vertical Franz cell diffusion studies and tape stripping methods were used to determine the in vitro, SC-epidermis and epidermis-dermis delivery of these formulations. Results and discussion: Stability tests showed that none of the formulations were completely stable. Acyclovir showed a biphasic character during the in vitro skin diffusion studies for all the tested formulations. The Pheroid™ cream enhanced the transdermal, SC-epidermis and epidermis-dermis delivery of acyclovir the most. The average amount of ketoconazole diffused over 12 h showed improved delivery of ketoconazole, with the Pheroid™ emulgel exhibiting the best transdermal and epidermis-dermis delivery. Conclusion: The Pheroid™ formulae increased transdermal penetration as well as delivery to the dermal and epidermal skin layers. The Pheroid™ emulgel and the Pheroid™ cream increased the topical delivery of ketoconazole and acyclovir, respectively. http://www.tandfonline.com/toc/idrd20/current |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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