Clinical and laboratory-reconfirmed myasthenia gravis: a population-based study
| Autor: | M. Ööpik, John Jakobsen, L. Puksa, A.-E. Kaasik, Siiri-Merike Lüüs |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Estonia Male medicine.medical_specialty Weakness Referral Adolescent medicine.drug_class Neural Conduction Neurophysiology Severity of Illness Index Community Health Planning Internal medicine Epidemiology Myasthenia Gravis Prevalence Medicine Humans Receptors Cholinergic Repetitive nerve stimulation Child Aged Retrospective Studies Aged 80 and over business.industry Electromyography Medical record Middle Aged medicine.disease Myasthenia gravis Surgery Population based study Neurology Acetylcholinesterase inhibitor Child Preschool Female Neurology (clinical) Cholinesterase Inhibitors medicine.symptom business |
| Zdroj: | European journal of neurology. 15(3) |
| ISSN: | 1468-1331 |
| Popis: | The aim of this study was to compare the clinically based prevalence of myasthenia gravis (MG) with the prevalence of laboratory-confirmed cases. All patients with a diagnosis of MG living in Estonia as on 1 January 1997 were asked to participate in re-examination. The criteria for laboratory-supported MG were weakness and rapid fatigue and a positive outcome of at least one of three laboratory tests: (i) blinded acetylcholinesterase inhibitor test; (ii) determination of antibodies to acetylcholine receptor and (iii) neurophysiological examination using repetitive nerve stimulation and single-fibre EMG. Eighty-nine patients were re-examined and 70 patients (79%) fulfilled the criteria of laboratory-supported MG. The corrected prevalence ratio was 78 per million. In the non-confirmed MG group, there was more women (92%) than men (43%) whose diagnosis was established within 1 year from onset of symptoms (P = 0.016). In all women with non-confirmed MG the diagnosis was established within 1 year from referral to the physician, whereas 68% of women with confirmed MG was diagnosed within 1 year (P < 0.0001). Thus, we conclude that, in Estonia the prevalence of MG based on medical records seems overestimated by 21% and women are at higher risk of obtaining an uncertain diagnosis of MG. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text