Evolution of a Novel Tissue Preservation Protocol to Optimize Osteochondral Transplantation Outcomes
| Autor: | Ziad Abusara, Scott Timmermann, David Cinats, Norman S. Schachar, S. Mark Heard, Susan L.M. Miller, Carol Hutchison |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Allograft transplantation Tissue and Organ Procurement Adolescent Knee Joint Arthroplasty Subchondral Biomedical Engineering Physical Therapy Sports Therapy and Rehabilitation Knee Injuries Osteoarthritis Disability Evaluation Young Adult 03 medical and health sciences 0302 clinical medicine Clinical Research Papers Cartilage transplantation medicine Humans Transplantation Homologous Immunology and Allergy Prospective Studies 030203 arthritis & rheumatology Tissue Preservation Shoulder Joint business.industry 030229 sport sciences Middle Aged Allografts medicine.disease Surgery Osteochondral transplantation Cartilage Functional Status Treatment Outcome Transplanted tissue Female Shoulder Injuries business |
| Zdroj: | Cartilage |
| ISSN: | 1947-6043 1947-6035 |
| Popis: | ObjectiveOsteochondral allograft transplantation is a procedure to treat focal osteochondral lesions (OCLs), but is limited by tissue availability, the quality of transplanted tissue, and inconsistent storage protocols. The objective of this study was to assess the clinical outcomes of a novel tissue procurement, storage, and quality control protocol in treating OCLs.DesignProspective case series. Donor cadaveric tissue was processed, stored, and the tissue quality analyzed using the unique tissue preservation protocol developed at our institution. Advanced cross-sectional imaging was used to size match donor tissue with recipient patients. Osteochondral allografts were transplanted using the Arthrex Allograft OATS. Patients were evaluated with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Knee injury and Osteoarthritis Outcome Score (KOOS), visual analog scale (VAS), and 36-Item Short Form Survey (SF-36) preoperatively and at 1 year and 2 years postoperatively.ResultsTwenty patients (17 knees, 3 shoulders) were included in the study. There was a significant improvement in the following scores: overall WOMAC score, WOMAC function and pain subcategories; KOOS pain, knee-related symptoms, activities of daily living, sports and recreation, and quality of life; SF-36 physical functioning, physical role, pain, and social functioning subcategories; and VAS at all time points postoperatively. There was a significant improvement in WOMAC stiffness at 2 years postoperatively. There were 2 failures, defined by graft subsidence and persistent pain requiring reoperation.ConclusionThe protocol developed at our institution for OAT resulted in significant clinical improvement in patients with OCLs and is an improvement on existing tissue storage techniques. |
| Databáze: | OpenAIRE |
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