Increased risk of pulmonary and extrapulmonary tuberculosis infection in patients with polycystic kidney disease: a nationwide population-based study with propensity score-matching analysis

Autor:	Mei-Chen Lin, Chih-Wei Chiu, Brian K. Lee, Tung-Min Yu, Tsuo-Hung Lan, Ting-Fang Chiu, Chi Yuan Li, Chia-Hung Kao
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	medicine.medical_specialty Tuberculosis Population 030232 urology & nephrology General Biochemistry Genetics and Molecular Biology Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Polycystic kidney disease Internal medicine Lymphopenia Medicine Humans 030212 general & internal medicine education Propensity Score Tuberculosis Pulmonary Retrospective Studies education.field_of_study Polycystic Kidney Diseases business.industry Research Hazard ratio General Medicine Mycobacterium tuberculosis medicine.disease musculoskeletal system Comorbidity Cohort Propensity score matching cardiovascular system business Cohort study
Zdroj:	Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-7 (2021) Journal of Translational Medicine
ISSN:	1479-5876
Popis:	Background Polycystic kidney disease (PKD) is a common renal disorder affecting approximately 1 in 1000 live births. Tuberculosis (TB) is an infectious disease worldwide. This study investigated the risk of TB infection in patients with PKD. Methods A nationwide population-based cohort study was performed using Taiwan’s National Health Insurance Research Database. We used patients’ hospitalization files for the entire analysis during 2000–2012. As per diagnosis, we divided patients into PKD and non-PKD cohorts and the major outcome was TB infection. Results A total of 13,540 participants with 6770 patients in each cohort were enrolled. The PKD cohort had a higher risk of TB infection than did the non-PKD cohort after adjusting for age, sex, and comorbidities (adjusted hazard ratio (aHR) = 1.91, 95% confidence interval [CI] = 1.51–2.43). When classifying by sites of pulmonary TB (PTB) and extrapulmonary TB (EPTB), the PKD cohort demonstrated a significantly higher risk of EPTB (aHR = 2.44, 95% CI = 1.46–4.08) as well as a risk of PTB (aHR = 1.69, 95% CI = 1.29–2.22). When stratified by the presence or absence of a comorbidity, high TB infection risk was noted in the PKD patients without any comorbidity (HR = 2.69, 95% CI = 1.69–4.30). Conclusions Taken together, our findings suggest that PKD is associated with a 1.91-fold increased risk of TB infection. Medical professionls should maintain a high index of suspicion in daily practice for patients with PKD, particularly those with EPTB infection.
Databáze:	OpenAIRE
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