Transformation of QTL genotypic effects to allelic effects

Autor: Yoshitaka Nagamine
Přispěvatelé: Revues Inra, Import
Jazyk: angličtina
Předmět:
lcsh:QH426-470
Genotype
QTL
Quantitative Trait Loci
allelic effect
[SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics
Biology
Quantitative trait locus
Genome
03 medical and health sciences
genotypic effect
Genetics
Animals
Genetics(clinical)
Allele
Additive model
Selection (genetic algorithm)
Alleles
Ecology
Evolution
Behavior and Systematics
lcsh:SF1-1100
030304 developmental biology
0303 health sciences
Research
transformation
0402 animal and dairy science
Chromosome Mapping
food and beverages
04 agricultural and veterinary sciences
General Medicine
Quantitative genetics
Marker-assisted selection
040201 dairy & animal science
lcsh:Genetics
[SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics
marker assist selection
Data Interpretation
Statistical
Animal Science and Zoology
lcsh:Animal culture
Zdroj: Genetics, Selection, Evolution : GSE
Genetics Selection Evolution
Genetics Selection Evolution, BioMed Central, 2005, 37 (5), pp.579-584
Genetics Selection Evolution, Vol 37, Iss 6, Pp 579-584 (2005)
ISSN: 1297-9686
0999-193X
DOI: 10.1186/1297-9686-37-6-579
Popis: The genotypic and allelic effect models are equivalent in terms of QTL detection in a simple additive model, but the QTL allelic model has the advantage of providing direct information for marker-assisted selection. However, the allelic matrix is four times as large as the genotypic IBD matrix, causing computational problems, especially in genome scans examining multiple positions. Transformation from genotypic to allelic effects, after estimating the genotypic effects with a smaller IBD matrix, can solve this problem. Although the validity of transformation from genotypic to allelic effects has been disputed, this work proves that transformation can successfully yield unique allelic effects when genotypic and allelic IBD matrixes exist.
Databáze: OpenAIRE
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