Amniotic fluid lamellar body counts for the determination of fetal lung maturity: an update
| Autor: | Luisa Fumian, Juan Piazze, Paolo Meloni, Maurizio M. Anceschi, Luca Maranghi, Stefano Gioia, Ermelando V. Cosmi, A. Cerekja |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
fetal lung maturity Amniotic fluid Gestational Age Fetal Organ Maturity Pregnancy Prenatal Diagnosis Humans Medicine Neonatology Lung Phospholipids Respiratory Distress Syndrome Newborn Receiver operating characteristic medicine.diagnostic_test business.industry Obstetrics Infant Newborn Obstetrics and Gynecology Gestational age lamellar body counts Amniotic Fluid medicine.disease Confidence interval Surgery Pediatrics Perinatology and Child Health Amniocentesis Female Lamellar body count business |
| Zdroj: | Journal of Perinatal Medicine. 33 |
| ISSN: | 1619-3997 0300-5577 |
| DOI: | 10.1515/jpm.2005.029 |
| Popis: | Aim: To reassess the cut-off value for lamellar body counts (LBs) for fetal lung maturity (FLM) over a 10-year study period. Patients and methods: 178 pregnancies were selected under strict inclusion criteria and delivered within 48 h from amniocentesis. FLM was determined by amniotic fluid LBs in centrifuged samples (300×g for 10 min) in a commercially available Coulter Counter. Cases beyond 37 weeks were excluded. Results: Mean gestational age was 33.5±3.0 weeks at amniocentesis and 33.7±3.0 weeks at birth. After reassessing the best compromise between sensitivity and specificity for all cases using the receiver operating characteristic (ROC) procedure, an FLM cut-off value of ≤22,000/μL was obtained. Diagnostic accuracy (and confidence interval, Cl) was: sensitivity, 73% (60.0-83.6%); specificity, 81.7% (Cl 73.6-88.1%); positive predictive value, 66.2%; and negative predictive value, 86.0%. Conclusion: No significant change in FLM cut-off for LBs was found when comparing the value from this study and the results of our earlier report presented in 1996 (≤22,000 vs. ≤20,000/μL), although the new value may be more accurate, since it is based on neonatal outcome with the exclusion of cases in which the diagnosis of FLM is seldom warranted, i.e., > 37 weeks' gestational age. |
| Databáze: | OpenAIRE |
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