Protective effects of nigella sativa against gentamicin-induced nephrotoxicity in rats
| Autor: | Engin Balikci, Ihsan Yaman |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Lumen (anatomy) Biology Kidney Toxicology medicine.disease_cause Pathology and Forensic Medicine Nephrotoxicity chemistry.chemical_compound Internal medicine medicine Animals Plant Oils Nigella sativa Rats Wistar Creatinine Free Radical Scavengers Cell Biology General Medicine Anti-Bacterial Agents Rats Oxidative Stress Mononuclear cell infiltration medicine.anatomical_structure Endocrinology chemistry Biochemistry Toxicity Urea Kidney Diseases Gentamicins Oxidative stress Phytotherapy |
| Zdroj: | Experimental and Toxicologic Pathology. 62:183-190 |
| ISSN: | 0940-2993 |
| Popis: | The aim of this study was focused on investigating the possible protective effect of NS against GS-induced nephrotoxicity. Twenty four Wistar-albino rats were divided into four equal groups as follows: control group, GS group (100mg/kg intraperitoneal - i.p.), NSL+GS group (0.2 ml/kg+100mg/kg i.p.) and NSH+GS group (0.4 ml/kg+100mg/kg i.p.). Plasma creatinine and urea levels significantly increased as a result of nephrotoxicity in the GS group. Also, creatinine and urea levels significantly decreased in NSL+GS and NSH+GS groups. In the GS group, plasma MDA and NO levels increased significantly (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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