A plasma protein derived TGFβ signature is a prognostic indicator in triple negative breast cancer
Autor: | Makoto Kobayashi, Hong Wang, Peiling Tsou, Michela Capello, Hiroyuki Katayama, Mary L. Disis, Francisco J. Esteva, Samir M. Hanash |
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Rok vydání: | 2019 |
Předmět: |
0303 health sciences
Cancer Research business.industry lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease lcsh:RC254-282 Blood proteins Article 3. Good health Metastasis 03 medical and health sciences 0302 clinical medicine Text mining Oncology Tumor progression 030220 oncology & carcinogenesis Proteome Tumor stage medicine Cancer research business Gene Triple-negative breast cancer 030304 developmental biology |
Zdroj: | NPJ Precision Oncology npj Precision Oncology, Vol 3, Iss 1, Pp 1-8 (2019) |
ISSN: | 2397-768X |
Popis: | We investigated the potential of in-depth quantitative plasma proteome analysis to uncover proteins predictive of progression and metastasis in triple negative breast cancer (TNBC). Analysis of samples from 24 pre-menopausal and 24 post-menopausal women with newly diagnosed TNBC who subsequently developed metastasis or remained metastasis free were utilized in the proteomic discovery set, which resulted in 43 proteins associated with tumor progression. These proteins were found to form a hierarchical network with TGFβ. The signature was further confirmed and refined by integrating plasma protein data from a murine TNBC model that encompassed mice with rapid- versus slow-growing tumors. Three genes consisting of CLIC1, MAPRE1, and SERPINA3 in the refined TGFβ signature significantly stratified overall survival (log-rank p = 0.0141) in a larger validation cohort irrespective of menopausal status, tumor stage, grade, and size. |
Databáze: | OpenAIRE |
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