The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure
| Autor: | Petr Volf, Marie Lipoldová, Michaela Vlkova, Iva Rohousova, Jitka Hostomska, Tetyana Kobets |
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| Rok vydání: | 2011 |
| Předmět: |
Veterinary medicine
Saliva Time Factors Leishmaniasis Cutaneous Biology Mice stomatognathic system parasitic diseases medicine Animals Humans Phlebotomus duboscqi Leishmania major Bites and Stings Mice Inbred BALB C fungi Leishmaniasis medicine.disease Leishmania biology.organism_classification Virology Insect Vectors Infectious Diseases Phlebotomus Vector (epidemiology) Female Parasitology |
| Zdroj: | International Journal for Parasitology. 41:481-485 |
| ISSN: | 0020-7519 |
| DOI: | 10.1016/j.ijpara.2011.01.003 |
| Popis: | Under laboratory conditions, hosts exposed twice to sand fly saliva are protected against severe leishmaniasis. However, people in endemic areas are exposed to the vector over a long term and may experience sand fly-free periods. Therefore, we exposed mice long- or short-term to Phlebotomus duboscqi bites, followed by Leishmania major infection either immediately or after a sand fly-free period. We showed that protection against leishmaniasis is limited to short-term exposure to sand flies immediately before infection. Our results may explain the persistence of leishmaniasis in endemic areas and should be taken into account when designing anti-Leishmania vaccines based on sand fly saliva. |
| Databáze: | OpenAIRE |
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