Thalamic circuits for independent control of prefrontal signal and noise
| Autor: | Arghya Mukherjee, Michael M. Halassa, Norman H Lam, Ralf D. Wimmer |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Mediodorsal Thalamic Nucleus Computer science Decision Making Prefrontal Cortex Neurophysiology Kainate receptor Article Receptors Dopamine Mice GRIK4 Receptors Kainic Acid Thalamus Interneurons Neural Pathways Animals Humans Prefrontal cortex Projection (set theory) Multidisciplinary biology Uncertainty Cognition Noise Dopamine receptor Cognitive control biology.protein Female Neuroscience |
| Zdroj: | Nature |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/s41586-021-04056-3 |
| Popis: | Interactions between the mediodorsal thalamus and the prefrontal cortex are critical for cognition. Studies in humans indicate that these interactions may resolve uncertainty in decision-making1, but the precise mechanisms are unknown. Here we identify two distinct mediodorsal projections to the prefrontal cortex that have complementary mechanistic roles in decision-making under uncertainty. Specifically, we found that a dopamine receptor (D2)-expressing projection amplifies prefrontal signals when task inputs are sparse and a kainate receptor (GRIK4) expressing-projection suppresses prefrontal noise when task inputs are dense but conflicting. Collectively, our data suggest that there are distinct brain mechanisms for handling uncertainty due to low signals versus uncertainty due to high noise, and provide a mechanistic entry point for correcting decision-making abnormalities in disorders that have a prominent prefrontal component2–6. Two different cell types in the mediodorsal thalamus have complementary roles in decision-making, with one type of mediodorsal projection amplifying prefrontal activity under low signal levels and one type suppressing it under high noise levels. |
| Databáze: | OpenAIRE |
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