Effects of trifluoroacetic acid, a halothane metabolite, on C6 glioma cells
| Autor: | Y H Ling, M T Tseng, G D McClure, T G Ma |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Ribonucleotide
Glycosylation Metabolite Cell Mannose Oligosaccharides Toxicology chemistry.chemical_compound Mice Leucine medicine Trifluoroacetic acid Tumor Cells Cultured Animals Trifluoroacetic Acid Glycoproteins chemistry.chemical_classification Chemistry Cell growth DNA Neoplasm Glioma Pollution medicine.anatomical_structure Mechanism of action Biochemistry medicine.symptom Glycoprotein Cell Division Thymidine |
| Zdroj: | Journal of toxicology and environmental health. 31(2) |
| ISSN: | 0098-4108 |
| Popis: | Effects of trifluoroacetic acid (TFA) on cell growth, DNA, glycoprotein, and dolichol-linked oligosaccharides synthesis and ribonucleotide triphosphate concentrations were examined in exponentially growing C6 murine glioma cells. One day of treatment with TFA caused a slight concentration-dependent enhancement of cell growth and [3H]thymidine incorporation. Exposure for 1 or 5 d to TFA (0.5-7.0 mM) elevated the [3H]leucine incorporation in a dose- and time-dependent manner. The results suggested that TFA stimulated cell growth and enhanced protein synthesis. TFA also affected [3H]mannose incorporation into glycoproteins and dolichol-linked oligosaccharides in a dose-dependent fashion. In addition, it was found that TFA accelerated lectin-induced cell agglutination. These data suggest that TFA, the principle halothane metabolite, alters plasmalemmal glycoprotein synthesis. These findings should form a basis for further understanding on the mechanism underlying halothane-associated neurotoxicity. |
| Databáze: | OpenAIRE |
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