Differential diagnosis between osteomyelitis and bone tumors
| Autor: | Takashi Sugita, Toshihiro Matsuo, Tadahiko Kubo, Mitsuo Ochi, Hiroo Nobuto, Shouji Shimose |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Adolescent Radiography Bone Neoplasms Sensitivity and Specificity Diagnosis Differential Humans Medicine Radiology Nuclear Medicine and imaging Femur Child Aged Retrospective Studies Tibia Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Osteomyelitis Penumbra Granulation tissue Magnetic resonance imaging Retrospective cohort study General Medicine Humerus Middle Aged medicine.disease Magnetic Resonance Imaging Radius C-Reactive Protein medicine.anatomical_structure Child Preschool Female Radiology Differential diagnosis Osteitis business |
| Zdroj: | Acta Radiologica. 49:928-933 |
| ISSN: | 1600-0455 0284-1851 |
| Popis: | Background: Hematogenous osteomyelitis is often difficult to distinguish from a bone tumor because clinical findings are noncontributory and radiological features can mimic a bone tumor. Recently, the penumbra sign, a higher signal intensity feature of the thin layer of granulation tissue which lines the abscess cavity on T1-weighted magnetic resonance (MR) images, has been reported to be helpful for discriminating subacute osteomyelitis. Purpose: To determine helpful findings for distinguishing osteomyelitis from bone tumors. Material and Methods: The laboratory and imaging findings of a consecutive series of 244 patients referred to our institution with a suspected bone tumor were reviewed. There were 15 cases of osteomyelitis, 160 bone tumors, and 69 tumor-like lesions. Results: In osteomyelitis, the C-reactive protein (CRP) level increased in nine patients and the penumbra sign was seen in 11 patients. In bone tumors and tumor-like lesions, a high CRP level was observed in 21 patients and the penumbra sign was seen in two patients. The sensitivity of the penumbra sign for osteomyelitis was 73.3%, with a specificity of 99.1%. Conclusion: The penumbra sign and a high CRP level support the diagnosis of osteomyelitis and may help to exclude the presence of a tumor. |
| Databáze: | OpenAIRE |
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