Pharmacogenomics of multifactorial diseases: a focus on psoriatic arthritis
| Autor: | Paola Borgiani, Giuseppe Novelli, Raffaella Cascella, Emiliano Giardina, Mara Maccarone, Claudia Strafella, Giuliana Longo, Federica Sangiuolo |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty High variability Context (language use) Pharmacology 03 medical and health sciences Psoriatic arthritis Quality of life (healthcare) Genetics Humans Medicine Disease management (health) Intensive care medicine Tumor Necrosis Factor-alpha business.industry Anti-Inflammatory Agents Non-Steroidal Arthritis Psoriatic Precision medicine medicine.disease 030104 developmental biology Settore MED/03 - Genetica Medica Pharmacogenetics Pharmacogenomics Quality of Life Molecular Medicine business |
| Zdroj: | Pharmacogenomics. 17:943-951 |
| ISSN: | 1744-8042 1462-2416 |
| DOI: | 10.2217/pgs.16.20 |
| Popis: | This review will outline the current pharmacogenomics knowledge about psoriatic arthritis with a special attention to the perspectives and the challenges for its implementation in the clinical practice. To date, different drugs have been developed to contrast the symptoms and the progression of psoriatic arthritis. However, patients have shown high variability of drug response in relation to their genetic makeup. In this context, the advances made in the knowledge and the potentialities of genome-drugs associations paved the path for the development of a precision medicine. In fact, these associations may be successfully combined with the environment information to provide new strategies able to prevent and improve the disease management as well as to enhance the patients quality of life. |
| Databáze: | OpenAIRE |
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