Association between Neutrophil Percentage-to-Albumin Ratio and All-Cause Mortality in Critically Ill Patients with Coronary Artery Disease
| Autor: | Tienan Sun, Chenghui Cai, Hua Shen, Yaodong Ding, Guangyao Zhai, Yujie Zhou, Jingrui Zhang, Qianyun Guo, Biyang Zhang, Jiaqi Yang |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Article Subject Neutrophils Critical Illness Subgroup analysis Coronary Artery Disease Kaplan-Meier Estimate 030204 cardiovascular system & hematology General Biochemistry Genetics and Molecular Biology Coronary artery disease 03 medical and health sciences 0302 clinical medicine Percutaneous Coronary Intervention Risk Factors Internal medicine medicine Clinical endpoint Humans 030212 general & internal medicine Serum Albumin Aged Proportional Hazards Models Aged 80 and over General Immunology and Microbiology Critically ill business.industry Mortality rate Confounding Albumin General Medicine Middle Aged medicine.disease Prognosis Cardiology Medicine Female business All cause mortality Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2020 (2020) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Background. Neutrophil percentage-to-albumin ratio (NPAR) has been proved to be associated with clinical outcome of many diseases. This study was aimed at exploring the independent effect of NPAR on all-cause mortality of critically ill patients with coronary artery disease (CAD). Method. NPAR was calculated as neutrophil percentage numerator divided by serum albumin concentration. Clinical endpoints were 30-day, 90-day, and 365-day all-cause mortality. Multivariable Cox proportional hazard models were performed to confirm the association between NPAR and all-cause mortality. Result. 3106 patients with CAD were enrolled. All-cause mortality rates of 30 days (P<0.001), 90 days (P<0.001), and 365 days (P<0.001) increased as NPAR tertiles increased. And after adjusting for possible confounding variables, NPAR was still independently associated with 30-day (third tertile group versus first tertile group: HR, 95% CI: 1.924, 1.471-2.516; P for trend < 0.001), 90-day (third tertile group versus first tertile group: HR, 95% CI: 2.053, 1.646-2.560; P for trend < 0.001), and 365-day (third tertile group versus first tertile group: HR, 95% CI: 2.063, 1.717-2.480; P for trend < 0.001) all-cause mortality in patients with CAD. Subgroup analysis did not find obvious interaction in most subgroups. Conclusion. NPAR was independently correlated with 30-day, 60-day, and 365-day all-cause mortality in critically ill patients with CAD. |
| Databáze: | OpenAIRE |
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