A Comparison of Five Different Treatment Regimens as the First-Line Treatment of Helicobacter pylori in Turkey
| Autor: | Gulsum Teke Ozgur, Aydın Karakoca, Ozgur Hilal Erinanc, Huseyin Savas Gokturk, Gulhan Kanat Unler |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Turkey Helicobacter Infections Treatment and control groups 03 medical and health sciences 0302 clinical medicine Levofloxacin Clarithromycin Internal medicine medicine Outpatient clinic Humans Retrospective Studies biology Treatment regimen business.industry Gastroenterology Retrospective cohort study Proton Pump Inhibitors General Medicine Helicobacter pylori Middle Aged biology.organism_classification Surgery Anti-Bacterial Agents First line treatment Infectious Diseases Treatment Outcome 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Helicobacter. 21(4) |
| ISSN: | 1523-5378 |
| Popis: | Background The H. pylori eradication success is low in countries with high antibiotic resistance to H. pylori. Objective We retrospectively assessed the eradication rates achieved by five different regimens and aimed to compare the efficiency of bismuth enhanced sequential therapy and other treatments in a gastroenterology outpatient clinic a university-affiliated hospital. Design Our study was carried out with a retrospective cohort design. Setting This study assessed the gastroscopy examinations of patients. Patients A total of 621 patients were included in the study. There were 122 patients in the quadruple treatment group, 168 patients in the classical sequential treatment group, 130 patients in the bismuth enhanced sequential therapy, 113 patients in the sequential treatment with levofloxacin, and 88 patients in the hybrid treatment. Measurements Eradication rates of different regimens was analyzed by performing Chi-square and Tukey's honest significant difference test. Results Eradication rates by ITT and PP analysis achieved by treatment groups were 74.6 and 75.6% in the quadruple treatment; 70.2 and 70.4% in the sequential treatment with clarithromycin, 88.5 and 90.3% in the bismuth enhanced sequential therapy, 77.9 and 78.5% in the sequential treatment with levofloxacin, and 76.1 and 76.2% in the hybrid treatment. Limitations The main limitation of our study was its retrospective nature. Different proton pump inhibitors were used in the treatment arms. Conclusions Bismuth-enhanced sequential therapy can be recommended to overcome resistance. |
| Databáze: | OpenAIRE |
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