Ranitidine treatment and cortisol metabolism in man
| Autor: | Edgar E. Ohnhaus, H. M. Schulte, K. Hoffmann, H. Mönig |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone Metabolite Pharmacology Steroid biosynthesis Ranitidine chemistry.chemical_compound Pharmacokinetics Oral administration Internal medicine medicine Humans Pharmacology (medical) Biotransformation 17-Hydroxycorticosteroids Chemistry Endocrinology sense organs Antipyrine Drug metabolism Glucocorticoid medicine.drug |
| Zdroj: | European Journal of Drug Metabolism and Pharmacokinetics. 17:9-12 |
| ISSN: | 2107-0180 0378-7966 |
| DOI: | 10.1007/bf03189981 |
| Popis: | Experimental evidence suggested that H2-receptor antagonists may inhibit not only hepatic but also adrenal cytochrome P-450 dependent monooxygenases. Therefore, the effects of ranitidine (150 mg b.i.d. over 14 days) on cortisol metabolism and antipyrine clearance have been investigated in nine healthy volunteers. Urinary excretion of 6 beta-hydroxycortisol (6 beta-OHC) and 17-hydroxycorticosteroids (17-OHCS) remained unaffected by ranitidine pretreatment, as did the calculated 6 beta-OHC/17-OHCS ratio. Only marginal effects were observed on antipyrine kinetics and metabolite formation. We conclude that neither adrenal production of corticosteroids nor their hepatic metabolism is affected by ranitidine administration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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