A lysozyme corona complex for the controlled pharmacokinetic release of probucol from mesoporous silica particles
| Autor: | Alfonso E. Garcia-Bennett, Kalpeshkumar Giri, Irene Moroni, Michael Lau, Inga Kuschnerus |
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| Rok vydání: | 2020 |
| Předmět: |
Diffusion
Kinetics Biomedical Engineering Probucol Protein Corona Mesoporous silica Silicon Dioxide Controlled release chemistry.chemical_compound Solubility chemistry parasitic diseases medicine Muramidase General Materials Science Adsorption Lysozyme Porosity Protein adsorption Nuclear chemistry medicine.drug |
| Zdroj: | Biomaterials Science. 8:3800-3803 |
| ISSN: | 2047-4849 2047-4830 |
| Popis: | Mesoporous silica particles (MSPs) enhance the release kinetics of poorly soluble compound probucol (PB) under the influence of a pore-blocking protein corona, prepared with lysozyme protein adsorption. In vivo oral administration experiments show a prolongation in the time to reach maximum systemic concentration and half-life of PB released from the lysozyme-MSP complex in comparison to the MSP alone. Specific hard protein corona complexes can act as functional diffusion barriers for the controlled release of drugs from MSP based formulations. |
| Databáze: | OpenAIRE |
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