Impaired cutaneous reactive hyperaemia during hypoglycaemia in young insulin-dependent diabetic patients and healthy controls
| Autor: | T. Tuvemo, Christian Berne, J. Aman, U. Ewald |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Epinephrine Endocrinology Diabetes and Metabolism Hyperemia Vasodilation Norepinephrine Hyperaemia Insulin Infusion Systems Endocrinology Ischemia Reference Values Diabetes mellitus Internal medicine Internal Medicine medicine Humans Insulin Skin Plasma glucose business.industry Healthy subjects General Medicine Glucagon medicine.disease Control subjects Hypoglycemia Diabetes Mellitus Type 1 Regional Blood Flow Cardiology Forearm skin Female medicine.symptom business Insulin dependent |
| Zdroj: | Acta Diabetologica. 29:25-28 |
| ISSN: | 1432-5233 0940-5429 |
| Popis: | The aim of the present study was to compare the cutaneous postischaemic hyperaemic response in young insulin-dependent diabetic patients and healthy subjects during normoglycaemia, acute insulin-induced hypoglycaemia and in the posthypoglycaemic state. After a night of normoglycaemia the cutaneous postischaemic hyperaemic response in the forearm skin, measured by the transcutaneous PO2 method, was the same in both groups. A reduction of the maximal postischaemic vasodilatory response was observed in diabetic patients from 2.4 +/- 0.3 to 2.0 +/- 0.2 kPa (P less than 0.05) and in control subjects from 2.7 +/- 0.3 to 1.8 +/- 0.2 kPa (P less than 0.02) during insulin-induced hypoglycaemia (plasma glucose less than 2 mmol/l). Complete recovery of the vasodilatory response occurred in subjects in the posthypoglycaemic state. We conclude that hypoglycaemia induced a transient reduction of the vasodilatory response, which was rapidly reversed after glucose counter-regulation, in both diabetic patients and healthy controls. Thus, the prevailing blood glucose concentration must be taken into account when the postischaemic vasodilatory response is investigated in diabetic patients. |
| Databáze: | OpenAIRE |
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