Defective Osteogenic Differentiation in the Development of Osteosarcoma
| Autor: | Yuxi Su, Qiong Shi, Gao-Hui Zhu, Chad M. Teven, Gaurav Luther, Ning Hu, Mi Li, Ni Tang, Xing Liu, Eric R. Wagner, Rex C. Haydon, Tong-Chuan He, Qing Luo, Hue H. Luu, Liang Chen, Bai-Cheng He, Guo-Wei Zuo, Enyi Huang, Yanhong Gao, Jinyong Luo, Linyuan Wang, Ke Yang, Stephanie H. Kim, Yang Bi, Xiaoji Luo, Jian-Li Gao, Richard Rames |
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| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty Poor prognosis Review Article lcsh:RC254-282 Metastasis 03 medical and health sciences 0302 clinical medicine Medicine Radiology Nuclear Medicine and imaging 030304 developmental biology Bone growth 0303 health sciences business.industry Molecular pathogenesis High cell lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease 3. Good health RUNX2 Oncology 030220 oncology & carcinogenesis Cancer research Osteosarcoma High incidence business |
| Zdroj: | Sarcoma Sarcoma, Vol 2011 (2011) |
| ISSN: | 1369-1643 1357-714X |
| Popis: | Osteosarcoma (OS) is associated with poor prognosis due to its high incidence of metastasis and chemoresistance. It often arises in areas of rapid bone growth in long bones during the adolescent growth spurt. Although certain genetic conditions and alterations increase the risk of developing OS, the molecular pathogenesis is poorly understood. Recently, defects in differentiation have been linked to cancers, as they are associated with high cell proliferation. Treatments overcoming these defects enable terminal differentiation and subsequent tumor inhibition. OS development may be associated with defects in osteogenic differentiation. While early regulators of osteogenesis are unable to bypass these defects, late osteogenic regulators, including Runx2 and Osterix, are able to overcome some of the defects and inhibit tumor propagation through promoting osteogenic differentiation. Further understanding of the relationship between defects in osteogenic differentiation and tumor development holds tremendous potential in treating OS. |
| Databáze: | OpenAIRE |
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